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. 1973 Jun;52(6):1314–1319. doi: 10.1172/JCI107302

Effect of Changes in Hydrostatic Pressure in Peritubular Capillaries on the Permeability of the Proximal Tubule

John P Hayslett 1,2
PMCID: PMC302393  PMID: 4703221

Abstract

The effect of increased hydrostatic pressure in the peritubular vessels on net sodium reabsorption from the proximal tubule was examined in the Necturus. An increase in the pressure gradient of 2.0 cm H2O across the wall of the proximal tubule, produced by ligation of the postcaval vein was associated with a marked reduction in net reabsorption and an increased back flux of water and electrolytes. This change was accompanied by a slight, but significant drop in the transepithelial electrical potential but not by an alteration in the steady-state chemical gradient. These studies highlight the importance of changes in the permeability characteristics of the proximal tubule on net sodium transport.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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