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. Author manuscript; available in PMC: 2011 Jan 20.
Published in final edited form as: Circulation. 2010 Feb 1;121(6):833–840. doi: 10.1161/CIRCULATIONAHA.109.192695

TABLE 1.

Prospective Studies of the Effects of ADT on Cardiac Risk Factors

OUTCOME REFERENCE(S) OBSERVATIONS COMMENT
Obesity 16-20 Increased fat mass Fat accumulation is primarily subcutaneous fat
Serum lipids 18, 23 Increased LDL cholesterol and triglycerides HDL cholesterol is also increased
Insulin sensitivity 17, 24, 28 Increased fasting plasma insulin and decreased insulin sensitivity Small increase in glycosylated hemoglobin
Blood pressure 21 No significant change
Waist-hip ratio 21 No significant change
C-reactive protein 31 No significant change in C-reactive protein or other biomarkers of inflammation

LDL indicates low-density lipoprotein; HDL, high-density lipoprotein.