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. 1973 Aug;52(8):1931–1936. doi: 10.1172/JCI107377

Abnormalities in the Distribution of Serum Immunoglobulin Concentrations in Juvenile Rheumatoid Arthritis

James T Cassidy 1,2,3, Ross E Petty 1,2,3, Donita B Sullivan 1,2,3
PMCID: PMC302475  PMID: 4578296

Abstract

Concentrations of serum IgG. IgA, and IgM were determined in 200 patients with juvenile rheumatoid arthritis. The relative frequency distribution of IgG and IgM approached that of a log-normal curve; however, there was marked skewing of the distribution of the serum concentrations of IgA. The prevalence of selective IgA deficiency was 4%. In order to permit further intragroup comparisons, the serum immunoglobulin concentrations were standardized by comparison to a sex-age matched control group. By this process it was found that there was concordance of the serum levels of IgG with IgA, and IgG with IgM. The standardized concentrations of IgA and IgM were less in females than males. The aberration in distribution of serum IgA concentrations found in this study, and the relative inability of females to respond to their disease by increasing specific serum immunoglobulin levels, add further data supporting the concept of immunodeficiency in the pathogenesis of juvenile rheumatoid arthritis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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