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. 1973 Aug;52(8):2041–2052. doi: 10.1172/JCI107388

In Vivo Assessment of Pulmonary Vascular Integrity in Experimental Pulmonary Edema

Kenneth L Brigham 1, James D Snell Jr 1
PMCID: PMC302486  PMID: 4578297

Abstract

During single pass indicator studies across the lungs [14C]urea remains in the vascular compartment, but its molecular size and solubility suggest it might escape abnormally permeable vessels. To test the hypothesis that [14C]urea might be used to distinguish pulmonary edema due to acutely increased intravascular pressure from that due to vascular damage by alloxan, we studied [51Cr]erythrocytes (r), [125I]albumin (a), [14C]urea (u), and tritiated water as dilution indicators in the pulmonary circulation of anesthetized dogs. In addition, the adequacy of albumin as an intravascular indicator was evaluated.

Indicator curves, blood gases, hematocrit, and vascular pressures were determined during a base-line period and repeated 30 and 60 min after treatment in five groups of dogs: (a) saline control. (b) alloxan edema. (c) epinephrine infusion, (d) volume overload, and (e) left atrial (LA) balloon obstruction.

Groups b, d, and e developed a similar degree of edema judging by wet/dry lung weights and histology. Groups a and c did not develop edema. In alloxan edema, differences between the mean transit time volume of u and r (Vv-r) increased over base line at 30 (P < 0.001) and 60 min (P < 0.02); the differences between the mean transit time volume of a and r (Ve-r) increased slightly at 30 (P < 0.03) and 60 min (P < 0.02); and Vu-r significantly exceeded Va-r at 30 (mean difference = 9 ml, P < 0.02) and 60 min (mean difference = 11, P < 0.04). In none of the other groups did Vu-r significantly exceed Va-r. Thus, comparison of Vu-r with Va-r may permit distinction between “high pressure” and “increased permeability” pulmonary edema.

Albumin was not a consistently reliable indicator of intravascular volume as compared with composite red cell and albumin curve.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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