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. 1973 Nov;52(11):2848–2852. doi: 10.1172/JCI107480

Abnormal Bone Mineral Maturation in the Chronic Uremic State

Jean E Russell 1,2, John D Termine 1,2, Louis V Avioli 1,2
PMCID: PMC302552  PMID: 4748511

Abstract

X-ray diffraction analysis of bone from chronically uremic but nonacidotic rats with normocalcemia and hyperphosphatemia revealed smaller apatite crystals and an increase in the X-ray amorphous mineral fraction when compared to age-matched, pair-fed control animals, indicating less advanced mineral maturation in the uremic animals. Studies in animals with varied degrees of chronic renal insufficiency revealed a progression of the bone crystal maturational defect with advancing uremia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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