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. 1973 Dec;52(12):2973–2978. doi: 10.1172/JCI107494

Mechanics of Sphincter Action. STUDIES ON THE LOWER ESOPHAGEAL SPHINCTER

Piero Biancani 1,2,3, Raj K Goyal 1,2,3, Aris Phillips 1,2,3, Howard M Spiro 1,2,3
PMCID: PMC302570  PMID: 4750434

Abstract

The purpose of this study was to evaluate the mechanical factors involved in the genesis of lower esophageal sphincter pressure. We determined the relationship between intraluminal pressure and inside diameter, estimated the ratio between the wall thickness to inside radius, and calculated the tension in the wall of the lower esophageal sphincter as a function of the inside diameter. Various degrees of circumferential stretch were applied by introducing probes of different diameters in the rat lower esophageal sphincter in vivo. The intraluminal pressure produced by the lower esophageal sphincter around each probe was measured and pressure-diameter curves were constructed during (a) resting state, (b) contraction produced by electrical stimulation, and (c) relaxation produced by esophageal distension. The intraluminal pressure at an inside diameter of 0.5 mm was similar to that at inside diameter of 3.2 mm. This was true for the sphincter at rest as well as upon electrical stimulation. The pressure diameter curve, however, was sigmoid in shape; at first it showed a decline and then an increase followed by decline in pressure again with increasing diameters. The ratio of wall thickness to inside radius or the magnification factor varied with inside diameters as expected and this ratio increased steeply at small inside diameters. The tension diameter curves of the sphincter muscle showed that optimal tension development occurred not near sphincter closure but at a much wider diameter of 3.2 mm and that this muscle developed tension even at small luminal diameters. This behavior of the sphincter muscle ensures effective intraluminal pressure over a wide range of luminal diameters.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BURTON A. C. On the physical equilibrium of small blood vessels. Am J Physiol. 1951 Feb;164(2):319–329. doi: 10.1152/ajplegacy.1951.164.2.319. [DOI] [PubMed] [Google Scholar]
  2. Goyal R. K., Biancani P., Phillips A., Spiro H. M. Mechanical properties of the esophageal wall. J Clin Invest. 1971 Jul;50(7):1456–1465. doi: 10.1172/JCI106630. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hollis J. B., Castell D. O. Amplitude of esophageal peristalsis as determined by rapid infusion. Gastroenterology. 1972 Sep;63(3):417–422. [PubMed] [Google Scholar]
  4. INGELFINGER F. J. Esophageal motility. Physiol Rev. 1958 Oct;38(4):533–584. doi: 10.1152/physrev.1958.38.4.533. [DOI] [PubMed] [Google Scholar]
  5. Lipshutz W., Cohen S. Physiological determinants of lower esophageal sphincter function. Gastroenterology. 1971 Jul;61(1):16–24. [PubMed] [Google Scholar]
  6. Lund G. F., Christensen J. Electrical stimulation of esophageal smooth muscle and effects of antagonists. Am J Physiol. 1969 Nov;217(5):1369–1374. doi: 10.1152/ajplegacy.1969.217.5.1369. [DOI] [PubMed] [Google Scholar]
  7. Pope C. E., 2nd Effect of infusion on force of closure measurements in the human esophagus. Gastroenterology. 1970 May;58(5):616–624. [PubMed] [Google Scholar]
  8. Rinaldo J. A., Jr, Levey J. F. Correlation of several methods for recording esophageal sphincteral pressures. Am J Dig Dis. 1968 Oct;13(10):882–890. doi: 10.1007/BF02237574. [DOI] [PubMed] [Google Scholar]
  9. SONNENBLICK E. H. Implications of muscle mechanics in the heart. Fed Proc. 1962 Nov-Dec;21:975–990. [PubMed] [Google Scholar]
  10. Stephens N. L., Kroeger E., Mehta J. A. Force-velocity characteristics of respiratory airway smooth muscle. J Appl Physiol. 1969 Jun;26(6):685–692. doi: 10.1152/jappl.1969.26.6.685. [DOI] [PubMed] [Google Scholar]
  11. Tuch A., Cohen S. Lower esophageal sphincter relaxation: studies on the neurogenic inhibitory mechanism. J Clin Invest. 1973 Jan;52(1):14–20. doi: 10.1172/JCI107157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. WILKIE D. R. The mechanical properties of muscle. Br Med Bull. 1956 Sep;12(3):177–182. doi: 10.1093/oxfordjournals.bmb.a069546. [DOI] [PubMed] [Google Scholar]
  13. Winans C. S., Harris L. D. Quantitation of lower esophageal sphincter competence. Gastroenterology. 1967 May;52(5):773–778. [PubMed] [Google Scholar]

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