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. 1973 Dec;52(12):3028–3032. doi: 10.1172/JCI107501

Modulation of Plasma Aldosterone Concentration by Plasma Potassium in Anephric Man in the Absence of a Change in Potassium Balance

C Robert Cooke 1, John S Horvath 1, Michael A Moore 1, Turner Bledsoe 1, W Gordon Walker 1
PMCID: PMC302577  PMID: 4750439

Abstract

In studies on seven anephric patients, glucose and insulin administration before hemodialysis produced a significant reduction in plasma potassium concentration (mean reduction = 1.3, 1.7, and 1.4 meq/liter at 60, 120, and 180 min, respectively) which was accompanied by a significant and sustained reduction in plasma aldosterone concentration. There was a significant correlation between plasma aldosterone and plasma potassium concentration (r = +0.74, P < 0.001) and between changes in the concentration of plasma aldosterone occurring in individual patients and the corresponding changes in plasma potassium concentration (r = +0.52, P < 0.01). There was no significant change in plasma sodium concentration, and plasma corticoid concentration, which was monitored as an index of ACTH elaboration, was reduced at 60 min but increased subsequently as symptoms attributable to hypoglycemia were observed.

These studies demonstrate that plasma aldosterone concentration can be modulated acutely by transitory changes in plasma potassium concentration without a change in potassium balance. The effect of glucose and insulin administration on intracellular potassium in the adrenal cortex is uncertain, and although increased net movement of potassium into cells is the presumptive mechanism of the reduction in plasma potassium concentration, whether the potassium content of the adrenal cortex may have increased or decreased or remained essentially unchanged, cannot be inferred from our data.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDRES R., BALTZAN M. A., CADER G., ZIERLER K. L. Effect of insulin on carbohydrate metabolism and on potassium in the forearm of man. J Clin Invest. 1962 Jan;41:108–115. doi: 10.1172/JCI104452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BLISS E. L., SANDBERG A. A., NELSON D. H., EIK-NES K. The normal levels of 17-hydroxycorticosteroids in the peripheral blood of man. J Clin Invest. 1953 Sep;32(9):818–823. doi: 10.1172/JCI102798. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Balikian H. M., Brodie A. H., Dale S. L., Melby J. C., Tait J. F. Effect of posture on the metabolic clearance rate, plasma concentration and blood production rate of aldosterone in man. J Clin Endocrinol Metab. 1968 Nov;28(11):1630–1640. doi: 10.1210/jcem-28-11-1630. [DOI] [PubMed] [Google Scholar]
  4. Baumber J. S., Davis J. O., Johnson J. A., Witty R. T. Increased adrenocortical potassium in association with increased biosynthesis of aldosterone. Am J Physiol. 1971 Apr;220(4):1094–1099. doi: 10.1152/ajplegacy.1971.220.4.1094. [DOI] [PubMed] [Google Scholar]
  5. Bayard F., Beitins I. Z., Kowarski A., Migeon C. J. Measurement of plasma aldosterone by radioimmunoassay. J Clin Endocrinol Metab. 1970 Jul;31(1):1–6. doi: 10.1210/jcem-31-1-1. [DOI] [PubMed] [Google Scholar]
  6. Bayard F., Cooke C. R., Tiller D. J., Beitins I. Z., Kowarski A., Walker W. G., Migeon C. J. The regulation of aldosterone secretion in anephric man. J Clin Invest. 1971 Aug;50(8):1585–1595. doi: 10.1172/JCI106646. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Berson S. A., Yalow R. S. Radioimmunoassay of ACTH in plasma. J Clin Invest. 1968 Dec;47(12):2725–2751. doi: 10.1172/JCI105955. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Boyd J. E., Palmore W. P., Mulrow P. J. Role of potassium in the control of aldosterone secretion in the rat. Endocrinology. 1971 Mar;88(3):556–565. doi: 10.1210/endo-88-3-556. [DOI] [PubMed] [Google Scholar]
  9. Cannon P. J., Ames R. P., Laragh J. H. Relation between potassium balance and aldosterone secretion in normal subjects and in patients with hypertensive or renal tubular disease. J Clin Invest. 1966 Jun;45(6):865–879. doi: 10.1172/JCI105402. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Cooke C. R., Ruiz-Maza F., Kowarski A., Migeon C. J., Walker W. G. Regulation of plasma aldosterone concentration in anephric man and renal transplant recipients. Kidney Int. 1973 Mar;3(3):160–166. doi: 10.1038/ki.1973.24. [DOI] [PubMed] [Google Scholar]
  11. Cushman P., Jr Inhibition of aldosterone secretion by ouabain in dog adrenal cortical tissue. Endocrinology. 1969 Apr;84(4):808–813. doi: 10.1210/endo-84-4-808. [DOI] [PubMed] [Google Scholar]
  12. DAVIS J. O., URQUHART J., HIGGINS J. T., Jr The effects of alteration of plasma sodium and potassium concentration on aldosterone secretion. J Clin Invest. 1963 May;42:597–609. doi: 10.1172/JCI104750. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Dluhy R. G., Axelrod L., Underwood R. H., Williams G. H. Studies of the control of plasma aldosterone concentration in normal man. II. Effect of dietary potassium and acute potassium infusion. J Clin Invest. 1972 Aug;51(8):1950–1957. doi: 10.1172/JCI107001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Funder J. W., Blair-West J. R., Coghlan J. P., Denton D. A., Scoggins B. S., Wright R. D. Effect of (K+) on the secretion of aldosterone. Endocrinology. 1969 Aug;85(2):381–384. doi: 10.1210/endo-85-2-381. [DOI] [PubMed] [Google Scholar]
  15. GANN D. S., DELEA C. S., GILL J. R., Jr, THOMAS J. P., BARTTER F. C. CONTROL OF ALDOSTERONE SECRETION BY CHANGE OF BODY POTASSIUM IN NORMAL MAN. Am J Physiol. 1964 Jul;207:104–108. doi: 10.1152/ajplegacy.1964.207.1.104. [DOI] [PubMed] [Google Scholar]
  16. GROB D., LILJESTRAND A., JOHNS R. J. Potassium movement in normal subjects: effect on muscle function. Am J Med. 1957 Sep;23(3):340–355. doi: 10.1016/0002-9343(57)90315-7. [DOI] [PubMed] [Google Scholar]
  17. Haber E., Koerner T., Page L. B., Kliman B., Purnode A. Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. J Clin Endocrinol Metab. 1969 Oct;29(10):1349–1355. doi: 10.1210/jcem-29-10-1349. [DOI] [PubMed] [Google Scholar]
  18. Hellman L., Nakada F., Curti J., Weitzman E. D., Kream J., Roffwarg H., Ellman S., Fukushima D. K., Gallagher T. F. Cortisol is secreted episodically by normal man. J Clin Endocrinol Metab. 1970 Apr;30(4):411–422. doi: 10.1210/jcem-30-4-411. [DOI] [PubMed] [Google Scholar]
  19. Hsu T. H., Bledsoe T. Measurement of urinary free corticoids by competitive protein-binding radioassay in hypoadrenal states. J Clin Endocrinol Metab. 1970 Apr;30(4):443–448. doi: 10.1210/jcem-30-4-443. [DOI] [PubMed] [Google Scholar]
  20. JOHNSON B. B., LIEBERMAN A. H., MULROW P. J. Aldosterone excretion in normal subjects depleted of sodium and potassium. J Clin Invest. 1957 Jun;36(6 Pt 1):757–766. doi: 10.1172/JCI103480. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. LARAGH J. H., STOERK H. C. A study of the mechanism of secretion of the sodium-retaining hormone (aldosterone). J Clin Invest. 1957 Mar;36(3):383–392. doi: 10.1172/JCI103434. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Mayes D., Furuyama S., Kem D. C., Nugent C. A. A radioimmunoassay for plasma aldosterone. J Clin Endocrinol Metab. 1970 May;30(5):682–685. doi: 10.1210/jcem-30-5-682. [DOI] [PubMed] [Google Scholar]
  23. Orth D. N., Island D. P., Liddle G. W. Experimental alteration of the circadian rhythm in plasma cortisol (17-OHCS) concentration in man. J Clin Endocrinol Metab. 1967 Apr;27(4):549–555. doi: 10.1210/jcem-27-4-549. [DOI] [PubMed] [Google Scholar]

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