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. 1974 May;53(5):1434–1440. doi: 10.1172/JCI107691

Immunoglobulin in Clinically Uninvolved Skin in Systemic Lupus Erythematosus ASSOCIATION WITH RENAL DISEASE

James N Gilliam 1,2, Don E Cheatum 1,2, Eric R Hurd 1,2, Peter Stastny 1,2, Morris Ziff 1,2
PMCID: PMC302631  PMID: 4596508

Abstract

23 of 42, or 55%, of patients with systemic lupus erythematous had immunoglobulin deposits along the epidermal basement membrane of uninvolved skin (positive lupus band test [LBT]). In patients with low serum complement levels, 91% had a positive LBT), as compared with 15% in those with normal complement levels. The LBT was positive in 70% of patients with clinical and laboratory evidence of renal disease, but in only 31% of patients without renal disease. 81% of patients with the more severe histologic forms of lupus nephritis, i.e., proliferative glomerulonephritis and membranous glomerulonephritis, and positive tests, whereas only 23% with mesangial glomerulitis or normal histologic findings were positive. Immunoglobulins of the same class found in the skin were detected in the glomeruli of patients examined by renal biopsy. These results suggest that there is a relationship between the occurrence of immunoglobulin in the epidermal basement membrane and the presence of the more severe forms of lupus nephritis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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