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. 1974 May;53(5):1468–1472. doi: 10.1172/JCI107695

Formation of an Intermediate in Prostaglandin Biosynthesis and Its Association with the Platelet Release Reaction

J B Smith 1, Carol Ingerman 1, J J Kocsis 1, M J Silver 1
PMCID: PMC302635  PMID: 4825236

Abstract

A compound that could be converted to prostaglandin F2α by mild chemical reduction was formed by human platelets in response to arachidonic acid, collagen, or L-epinephrine. It was present in maximal amounts at about 1 min after addition of arachidonic acid or collagen to platelet-rich plasma. Its initial formation appeared to precede platelet aggregation by these agents and was closely correlated with the release of adenine nucleotides and radioactive 5-hydroxytryptamine from platelets. Moreover, the compound was itself found outside the platelets. This compound is probably an endoperoxide intermediate in prostaglandin biosynthesis and may be a trigger for the platelet release reaction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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