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. 1974 May;53(5):1497–1500. doi: 10.1172/JCI107699

Nephron Stop-Flow Pressure Response to Obstruction for 24 Hours in the Rat Kidney

William J Arendshorst 1, William F Finn 1, Carl W Gottschalk 1
PMCID: PMC302639  PMID: 4825239

Abstract

Complete ureteral ligation of 24-h duration significantly reduced stop-flow and estimated glomerular capillary pressures in nephrons accessible to micropuncture in obstructed kidneys. In kidneys without ureteral obstruction, a similar response occurred in single tubules blocked for 24 h without affecting nearby unblocked tubules. Thus, the response to tubular obstruction occurs on an individual nephron basis and results from constriction of individual afferent arterioles. The mechanism leading to the response is unknown, but a feedback mechanism operating through the juxtaglomerular apparatus of individual nephrons is an attractive possibility.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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