Table I.
Genotype | Treatment | Duration (weeks) | No. of mice treated | Surviving mice |
|
1 week after PhIP or DMSO (%) | 1 week after DSS (%) | ||||
hCYP1A | 200 mg/kg PhIP + 1.5% DSS | 6–10 | 58 | 52 (90) | 49 (84) |
hCYP1A | DMSO + 1.5% DSS | 6–10 | 20 | 20 (100) | 18 (90) |
hCYP1A | DMSO | 24 | 17 | 17 (100) | 17 (100) |
hCYP1A | 200 mg/kg PhIP | 16–24 | 30 | 28 (93) | 28 (93) |
Wild-type | 200 mg/kg PhIP + 1.5% DSS | 24 | 11 | 11 (100) | 11 (100) |
Wild-type | DMSO | 24 | 17 | 17 (100) | 17 (100) |
Wild-type | 200 mg/kg PhIP | 14–24 | 17 | 17 (100) | 17 (100) |
Mice were given 200 mg/kg PhIP or vehicle (DMSO) by oral gavage and 1 week later were given 0 or 1.5% DSS in the drinking water for 7 days. Duration indicates the number of weeks following PhIP or DMSO administration when the mice were sacrificed.