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. 2011 Jan 21;60(2):555–564. doi: 10.2337/db10-0827

FIG. 3.

FIG. 3.

Mixed chimerism with MHC-mismatched wild-type BM prevented T1D in transgenic BDC2.5-NOD mice. Transgenic BDC2.5-NOD mice were conditioned anti-CD3 (5 μg) on day −7. On day 0, the conditioned mice were transplanted with BM cells (50 × 106) from MHC-mismatched wild-type, MHC-mismatched MHC II−/− or MHC-matched H-2g7 C57BL/6 donors to induce mixed chimerism. Diabetes development was monitored weekly by both urine and blood glucose. A: Diabetes development curve after HCT (n = 12 for mice given conditioning alone or recipients given BM cells from MHC-mismatched wild-type donors; n = 7 for recipients given MHC-mismatched MHC II−/− donor BM cells; n = 8 for recipients given MHC-matched BM cells). B: Percent insulitis for recipients given MHC mismatched wild-type BM versus conditioning alone 120 days after transplantation (n = 4). C: Representative spleen chimerism pattern (n = 4). D: Representative thymus chimerism pattern (n = 4).