TABLE 2.

Effect of teglicar treatment on different parameters of db/db mice after long-term treatment (45 days unless otherwise specified)

	Control	Teglicar
Body weight (g)	40.0 ± 1.1	40.4 ± 2.2
Food intake (g/day)	6.71 ± 0.2	5.46 ± 0.4
Water intake (mL/day)	13.5 ± 0.2	9.38 ± 1.1*
Serum parameters
Glycemia (day 28) (mg/dL)	495 ± 28	250 ± 20*
Glycemia (day 35) (mg/dL)	570 ± 30	322 ± 25*
Glycemia (mg/dL)	576 ± 32	352 ± 25*
Fructosamine (mmol/L)	4.8 ± 0.1	3.36 ± 0.3*
Insulin (ng/mL)	2.81 ± 0.2	2.32 ± 0.3
Triglycerides (mg/dL)	80.7 ± 5.5	82.2 ± 6.1
FFA (μmol/L)	1.98 ± 0.15	2.29 ± 0.1*
Cholesterol (mg/dL)	110.4 ± 10.1	112.4 ± 6.1
ALT (U/L)	82.9 ± 4.9	102.6 ± 7.2
Liver parameters
Liver weight (g)	1.94 ± 0.08	1.93 ± 0.09
Liver triglyceride content (mg/100 mg wt)	5.71 ± 0.9	8.54 ± 0.7*
Liver glycogen (μmol/g wt)	329 ± 54	255 ± 46

Data are means ± SE of eight mice.

*P < 0.05 vs. controls.