TABLE 2.
Single SNP genotypic association results for SNPs in the TCF7L2 gene showing association with type 2 diabetes ESRD
| Marker | Chromosome position (bp) | Alleles | MAF |
OR (95% CI) | Additive P value | |
|---|---|---|---|---|---|---|
| Cases (n = 982) | Controls (n = 1,039) | |||||
| rs7079711* | 114735778 | G/A | 0.44 | 0.43 | 1.00 (0.88–1.13) | 0.99 |
| rs4074720 | 114738737 | T/C | 0.23 | 0.25 | 0.95 (0.82–1.11) | 0.53 |
| rs4074718 | 114738857 | A/G | 0.23 | 0.25 | 0.93 (0.80–1.08) | 0.35 |
| rs11196182* | 114740397 | C/T | 0.26 | 0.28 | 0.85 (0.74–0.98) | 0.025 |
| rs17747324† | 114742743 | T/C | 0.08 | 0.07 | 1.26 (0.99–1.60) | 0.058 |
| rs4132115 | 114745736 | G/T | 0.19 | 0.15 | 1.23 (1.04–1.46) | 0.014 |
| rs4506565 | 114746281 | A/T | 0.51 | 0.47 | 1.15 (1.01–1.30) | 0.030 |
| rs7068741 | 114746498 | C/T | 0.19 | 0.15 | 1.24 (1.05–1.46) | 0.012 |
| rs7069007 | 114746525 | G/C | 0.14 | 0.11 | 1.23 (1.02–1.48) | 0.033 |
| rs7903146 | 114748589 | C/T | 0.35 | 0.29 | 1.35 (1.18–1.54) | 1.76 × 10−5 |
| rs11196187 | 114749685 | G/A | 0.06 | 0.05 | 1.29 (0.97–1.71) | 0.082 |
| rs7092484 | 114751173 | G/A | 0.28 | 0.26 | 1.07 (0.93–1.23) | 0.35 |
| rs12098651* | 114751959 | G/A | 0.24 | 0.22 | 1.09 (0.94–1.26) | 0.25 |
| rs6585198 | 114752477 | A/G | 0.18 | 0.21 | 0.85 (0.73–1.00) | 0.051 |
*Inconsistent with HWE in cases.
†Inconsistent with HWE in controls.