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. 1993 Mar;61(3):1146–1148. doi: 10.1128/iai.61.3.1146-1148.1993

Mapping of T-cell epitopes of flagellar antigen d of Salmonella muenchen.

T M Joys 1, N E Street 1
PMCID: PMC302853  PMID: 7679374

Abstract

Regions of the antigen d flagellin of Salmonella muenchen capable of causing the proliferation of repolymerized d flagellin-primed T cells were delineated by using dodecameric peptides. Three areas causing substantial DNA replication were identified, together with five areas eliciting less response. On the basis of known salmonella flagellin structure, the major areas were located in highly conserved regions of the molecule.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Gammon G., Geysen H. M., Apple R. J., Pickett E., Palmer M., Ametani A., Sercarz E. E. T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypes. J Exp Med. 1991 Mar 1;173(3):609–617. doi: 10.1084/jem.173.3.609. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Joys T. M., Schödel F. Epitope mapping of the d flagellar antigen of Salmonella muenchen. Infect Immun. 1991 Sep;59(9):3330–3332. doi: 10.1128/iai.59.9.3330-3332.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Joys T. M. The flagellar filament protein. Can J Microbiol. 1988 Apr;34(4):452–458. doi: 10.1139/m88-078. [DOI] [PubMed] [Google Scholar]
  4. Kanto S., Okino H., Aizawa S., Yamaguchi S. Amino acids responsible for flagellar shape are distributed in terminal regions of flagellin. J Mol Biol. 1991 Jun 5;219(3):471–480. doi: 10.1016/0022-2836(91)90187-b. [DOI] [PubMed] [Google Scholar]
  5. Newton S. M., Jacob C. O., Stocker B. A. Immune response to cholera toxin epitope inserted in Salmonella flagellin. Science. 1989 Apr 7;244(4900):70–72. doi: 10.1126/science.2468182. [DOI] [PubMed] [Google Scholar]
  6. Suhrbier A., Rodda S. J., Ho P. C., Csurhes P., Dunckley H., Saul A., Geysen H. M., Rzepczyk C. M. Role of single amino acids in the recognition of a T cell epitope. J Immunol. 1991 Oct 15;147(8):2507–2513. [PubMed] [Google Scholar]
  7. Wei L. N., Joys T. M. Covalent structure of three phase-1 flagellar filament proteins of Salmonella. J Mol Biol. 1985 Dec 20;186(4):791–803. doi: 10.1016/0022-2836(85)90397-3. [DOI] [PubMed] [Google Scholar]

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