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. 1993 Mar;61(3):1149–1151. doi: 10.1128/iai.61.3.1149-1151.1993

Safety and immunogenicity of Salmonella typhi Ty21a vaccine in young Thai children.

S J Cryz Jr 1, N Vanprapar 1, U Thisyakorn 1, T Olanratmanee 1, G Losonsky 1, M M Levine 1, S Chearskul 1
PMCID: PMC302854  PMID: 8432597

Abstract

Salmonella typhi Ty21a vaccine in a liquid formulation was evaluated in 634 Thai children 2 to 6 years of age. The seroconversion rate was 69% for those who received vaccine versus 14% for those who received placebo (P < 0.005). The immune responses among vaccine recipients ranged from 60% in 3-year-olds to 81% for 6-year-olds.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anand A. C., Kataria V. K., Singh W., Chatterjee S. K. Epidemic multiresistant enteric fever in eastern India. Lancet. 1990 Feb 10;335(8685):352–352. doi: 10.1016/0140-6736(90)90635-i. [DOI] [PubMed] [Google Scholar]
  2. Black R., Levine M. M., Young C., Rooney J., Levine S., Clements M. L., O'Donnell S., Hugues T., Germanier R. Immunogenicity of Ty21a attenuated "Salmonella typhi" given with sodium bicarbonate or in enteric-coated capsules. Dev Biol Stand. 1983;53:9–14. [PubMed] [Google Scholar]
  3. Edelman R., Levine M. M. Summary of an international workshop on typhoid fever. Rev Infect Dis. 1986 May-Jun;8(3):329–349. doi: 10.1093/clinids/8.3.329. [DOI] [PubMed] [Google Scholar]
  4. Levine M. M., Ferreccio C., Black R. E., Tacket C. O., Germanier R. Progress in vaccines against typhoid fever. Rev Infect Dis. 1989 May-Jun;11 (Suppl 3):S552–S567. doi: 10.1093/clinids/11.supplement_3.s552. [DOI] [PubMed] [Google Scholar]
  5. Levine M. M., Ferreccio C., Cryz S., Ortiz E. Comparison of enteric-coated capsules and liquid formulation of Ty21a typhoid vaccine in randomised controlled field trial. Lancet. 1990 Oct 13;336(8720):891–894. doi: 10.1016/0140-6736(90)92266-k. [DOI] [PubMed] [Google Scholar]
  6. Levine M. M., Herrington D., Murphy J. R., Morris J. G., Losonsky G., Tall B., Lindberg A. A., Svenson S., Baqar S., Edwards M. F. Safety, infectivity, immunogenicity, and in vivo stability of two attenuated auxotrophic mutant strains of Salmonella typhi, 541Ty and 543Ty, as live oral vaccines in humans. J Clin Invest. 1987 Mar;79(3):888–902. doi: 10.1172/JCI112899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Murphy J. R., Baqar S., Muñoz C., Schlesinger L., Ferreccio C., Lindberg A. A., Svenson S., Losonsky G., Koster F., Levine M. M. Characteristics of humoral and cellular immunity to Salmonella typhi in residents of typhoid-endemic and typhoid-free regions. J Infect Dis. 1987 Dec;156(6):1005–1009. doi: 10.1093/infdis/156.6.1005. [DOI] [PubMed] [Google Scholar]
  8. Murphy J. R., Grez L., Schlesinger L., Ferreccio C., Baqar S., Muñoz C., Wasserman S. S., Losonsky G., Olson J. G., Levine M. M. Immunogenicity of Salmonella typhi Ty21a vaccine for young children. Infect Immun. 1991 Nov;59(11):4291–4293. doi: 10.1128/iai.59.11.4291-4293.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Simanjuntak C. H., Paleologo F. P., Punjabi N. H., Darmowigoto R., Soeprawoto, Totosudirjo H., Haryanto P., Suprijanto E., Witham N. D., Hoffman S. L. Oral immunisation against typhoid fever in Indonesia with Ty21a vaccine. Lancet. 1991 Oct 26;338(8774):1055–1059. doi: 10.1016/0140-6736(91)91910-m. [DOI] [PubMed] [Google Scholar]
  10. Thisyakorn U., Mansuwan P., Taylor D. N. Typhoid and paratyphoid fever in 192 hospitalized children in Thailand. Am J Dis Child. 1987 Aug;141(8):862–865. doi: 10.1001/archpedi.1987.04460080048025. [DOI] [PubMed] [Google Scholar]

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