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. 1994 Jul;62(7):3004–3007. doi: 10.1128/iai.62.7.3004-3007.1994

Susceptibility of melanized and nonmelanized Cryptococcus neoformans to nitrogen- and oxygen-derived oxidants.

Y Wang 1, A Casadevall 1
PMCID: PMC302912  PMID: 8005689

Abstract

Melanized Cryptococcus neoformans cells were less susceptible than nonmelanized cells to the fungicidal effects of nitrogen- and oxygen-derived oxidants. The results support the hypothesis that the phenoloxidase enzyme system contributes to virulence by protecting C. neoformans against nitrogen- and oxygen-derived oxidative antimicrobial molecules produced by immune effector cells.

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Selected References

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