Figure 4.
LMB blocks cells in early G1a. Cell cycle progression during LBM treatment observed by time lapse (GFP-B23/NPM cells). At 0 minutes, telophase (asterisk) cells are visible after 2 hours of LMB, and blocked doublet of early G1 cells is visible on the right side. After 10 minutes PNB-containing B23/NPM are visible but not the incipient nucleolus (arrow) that will be visible after 40 minutes. After 60 minutes the telophase cells are blocked in early G1a.