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. 1994 Sep;62(9):4085–4086. doi: 10.1128/iai.62.9.4085-4086.1994

Relationship between superoxide dismutase and melanin in a pathogenic fungus.

E S Jacobson 1, N D Jenkins 1, J M Todd 1
PMCID: PMC303074  PMID: 8063430

Abstract

Since melanin is considered a virulence factor in Cryptococcus neoformans, its suppression at 37 degrees C has been perplexing. We now show an opposite thermal regulation of superoxide dismutase (SOD), consistent with a compensatory mechanism. Moreover, we demonstrate normal SOD and catalase levels in albino, oxygen-sensitive mutants. These results suggest that melanin is an antioxidant factor comparable in importance to SOD.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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