Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1994 Oct;62(10):4671–4674. doi: 10.1128/iai.62.10.4671-4674.1994

Mycobacterial lipoarabinomannan induces nitric oxide and tumor necrosis factor alpha production in a macrophage cell line: down regulation by taurine chloramine.

G B Schuller-Levis 1, W R Levis 1, M Ammazzalorso 1, A Nosrati 1, E Park 1
PMCID: PMC303164  PMID: 7927739

Abstract

Avirulent mycobacterium H37Ra lipoarabinomannan (LAM) elicited nitric oxide (NO) and tumor necrosis factor alpha in a dose-dependent manner in a murine macrophage cell line, RAW 264.7 cells. H37Ra LAM and recombinant gamma interferon were highly synergistic for NO production. The production of NO and the release of tumor necrosis factor alpha stimulated by H37Ra LAM plus recombinant gamma interferon in RAW 264.7 cells are inhibited by taurine chloramine.

Full text

PDF
4671

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams L. B., Fukutomi Y., Krahenbuhl J. L. Regulation of murine macrophage effector functions by lipoarabinomannan from mycobacterial strains with different degrees of virulence. Infect Immun. 1993 Oct;61(10):4173–4181. doi: 10.1128/iai.61.10.4173-4181.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barnes P. F., Chatterjee D., Abrams J. S., Lu S., Wang E., Yamamura M., Brennan P. J., Modlin R. L. Cytokine production induced by Mycobacterium tuberculosis lipoarabinomannan. Relationship to chemical structure. J Immunol. 1992 Jul 15;149(2):541–547. [PubMed] [Google Scholar]
  3. Barnes P. F., Fong S. J., Brennan P. J., Twomey P. E., Mazumder A., Modlin R. L. Local production of tumor necrosis factor and IFN-gamma in tuberculous pleuritis. J Immunol. 1990 Jul 1;145(1):149–154. [PubMed] [Google Scholar]
  4. Beckerman K. P., Rogers H. W., Corbett J. A., Schreiber R. D., McDaniel M. L., Unanue E. R. Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes. J Immunol. 1993 Feb 1;150(3):888–895. [PubMed] [Google Scholar]
  5. Bermudez L. E., Young L. S. Tumor necrosis factor, alone or in combination with IL-2, but not IFN-gamma, is associated with macrophage killing of Mycobacterium avium complex. J Immunol. 1988 May 1;140(9):3006–3013. [PubMed] [Google Scholar]
  6. Bradbury M. G., Moreno C. Effect of lipoarabinomannan and mycobacteria on tumour necrosis factor production by different populations of murine macrophages. Clin Exp Immunol. 1993 Oct;94(1):57–63. doi: 10.1111/j.1365-2249.1993.tb05977.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Chatterjee D., Khoo K. H., McNeil M. R., Dell A., Morris H. R., Brennan P. J. Structural definition of the non-reducing termini of mannose-capped LAM from Mycobacterium tuberculosis through selective enzymatic degradation and fast atom bombardment-mass spectrometry. Glycobiology. 1993 Oct;3(5):497–506. doi: 10.1093/glycob/3.5.497. [DOI] [PubMed] [Google Scholar]
  8. Chatterjee D., Lowell K., Rivoire B., McNeil M. R., Brennan P. J. Lipoarabinomannan of Mycobacterium tuberculosis. Capping with mannosyl residues in some strains. J Biol Chem. 1992 Mar 25;267(9):6234–6239. [PubMed] [Google Scholar]
  9. Chatterjee D., Roberts A. D., Lowell K., Brennan P. J., Orme I. M. Structural basis of capacity of lipoarabinomannan to induce secretion of tumor necrosis factor. Infect Immun. 1992 Mar;60(3):1249–1253. doi: 10.1128/iai.60.3.1249-1253.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Chujor C. S., Kuhn B., Schwerer B., Bernheimer H., Levis W. R., Bevec D. Specific inhibition of mRNA accumulation for lymphokines in human T cell line Jurkat by mycobacterial lipoarabinomannan antigen. Clin Exp Immunol. 1992 Mar;87(3):398–403. doi: 10.1111/j.1365-2249.1992.tb03009.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Deng W., Thiel B., Tannenbaum C. S., Hamilton T. A., Stuehr D. J. Synergistic cooperation between T cell lymphokines for induction of the nitric oxide synthase gene in murine peritoneal macrophages. J Immunol. 1993 Jul 1;151(1):322–329. [PubMed] [Google Scholar]
  12. Denis M. Interferon-gamma-treated murine macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediates. Cell Immunol. 1991 Jan;132(1):150–157. doi: 10.1016/0008-8749(91)90014-3. [DOI] [PubMed] [Google Scholar]
  13. Flesch I. E., Kaufmann S. H. Mechanisms involved in mycobacterial growth inhibition by gamma interferon-activated bone marrow macrophages: role of reactive nitrogen intermediates. Infect Immun. 1991 Sep;59(9):3213–3218. doi: 10.1128/iai.59.9.3213-3218.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Fukuda K., Hirai Y., Yoshida H., Nakajima T., Usui T. Free amino acid content of lymphocytes nd granulocytes compared. Clin Chem. 1982 Aug;28(8):1758–1761. [PubMed] [Google Scholar]
  15. Gazzinelli R. T., Oswald I. P., James S. L., Sher A. IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages. J Immunol. 1992 Mar 15;148(6):1792–1796. [PubMed] [Google Scholar]
  16. Green T. R., Fellman J. H., Eicher A. L., Pratt K. L. Antioxidant role and subcellular location of hypotaurine and taurine in human neutrophils. Biochim Biophys Acta. 1991 Jan 23;1073(1):91–97. doi: 10.1016/0304-4165(91)90187-l. [DOI] [PubMed] [Google Scholar]
  17. Kaplan G., Gandhi R. R., Weinstein D. E., Levis W. R., Patarroyo M. E., Brennan P. J., Cohn Z. A. Mycobacterium leprae antigen-induced suppression of T cell proliferation in vitro. J Immunol. 1987 May 1;138(9):3028–3034. [PubMed] [Google Scholar]
  18. Kröncke K. D., Kolb-Bachofen V., Berschick B., Burkart V., Kolb H. Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation. Biochem Biophys Res Commun. 1991 Mar 29;175(3):752–758. doi: 10.1016/0006-291x(91)91630-u. [DOI] [PubMed] [Google Scholar]
  19. Learn D. B., Fried V. A., Thomas E. L. Taurine and hypotaurine content of human leukocytes. J Leukoc Biol. 1990 Aug;48(2):174–182. [PubMed] [Google Scholar]
  20. Levis W. R., Meeker H. C., Schuller-Levis G., Sersen E., Brennan P. J., Fried P. Mycobacterial carbohydrate antigens for serological testing of patients with leprosy. J Infect Dis. 1987 Nov;156(5):763–769. doi: 10.1093/infdis/156.5.763. [DOI] [PubMed] [Google Scholar]
  21. Molloy A., Gaudernack G., Levis W. R., Cohn Z. A., Kaplan G. Suppression of T-cell proliferation by Mycobacterium leprae and its products: the role of lipopolysaccharide. Proc Natl Acad Sci U S A. 1990 Feb;87(3):973–977. doi: 10.1073/pnas.87.3.973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Moreno C., Mehlert A., Lamb J. The inhibitory effects of mycobacterial lipoarabinomannan and polysaccharides upon polyclonal and monoclonal human T cell proliferation. Clin Exp Immunol. 1988 Nov;74(2):206–210. [PMC free article] [PubMed] [Google Scholar]
  23. Moreno C., Taverne J., Mehlert A., Bate C. A., Brealey R. J., Meager A., Rook G. A., Playfair J. H. Lipoarabinomannan from Mycobacterium tuberculosis induces the production of tumour necrosis factor from human and murine macrophages. Clin Exp Immunol. 1989 May;76(2):240–245. [PMC free article] [PubMed] [Google Scholar]
  24. Nathan C. F., Hibbs J. B., Jr Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol. 1991 Feb;3(1):65–70. doi: 10.1016/0952-7915(91)90079-g. [DOI] [PubMed] [Google Scholar]
  25. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 1992 Sep;6(12):3051–3064. [PubMed] [Google Scholar]
  26. Park E., Quinn M. R., Wright C. E., Schuller-Levis G. Taurine chloramine inhibits the synthesis of nitric oxide and the release of tumor necrosis factor in activated RAW 264.7 cells. J Leukoc Biol. 1993 Aug;54(2):119–124. doi: 10.1002/jlb.54.2.119. [DOI] [PubMed] [Google Scholar]
  27. Prinzis S., Chatterjee D., Brennan P. J. Structure and antigenicity of lipoarabinomannan from Mycobacterium bovis BCG. J Gen Microbiol. 1993 Nov;139(11):2649–2658. doi: 10.1099/00221287-139-11-2649. [DOI] [PubMed] [Google Scholar]
  28. Roach T. I., Barton C. H., Chatterjee D., Blackwell J. M. Macrophage activation: lipoarabinomannan from avirulent and virulent strains of Mycobacterium tuberculosis differentially induces the early genes c-fos, KC, JE, and tumor necrosis factor-alpha. J Immunol. 1993 Mar 1;150(5):1886–1896. [PubMed] [Google Scholar]
  29. Rook G. A. Role of activated macrophages in the immunopathology of tuberculosis. Br Med Bull. 1988 Jul;44(3):611–623. doi: 10.1093/oxfordjournals.bmb.a072271. [DOI] [PubMed] [Google Scholar]
  30. Selmaj K. W., Raine C. S. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann Neurol. 1988 Apr;23(4):339–346. doi: 10.1002/ana.410230405. [DOI] [PubMed] [Google Scholar]
  31. Sibley L. D., Adams L. B., Krahenbuhl J. L. Inhibition of interferon-gamma-mediated activation in mouse macrophages treated with lipoarabinomannan. Clin Exp Immunol. 1990 Apr;80(1):141–148. doi: 10.1111/j.1365-2249.1990.tb06454.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Tachibana K., Chen G. J., Huang D. S., Scuderi P., Watson R. R. Production of tumor necrosis factor alpha by resident and activated murine macrophages. J Leukoc Biol. 1992 Mar;51(3):251–255. doi: 10.1002/jlb.51.3.251. [DOI] [PubMed] [Google Scholar]
  33. Thomas E. L., Grisham M. B., Jefferson M. M. Preparation and characterization of chloramines. Methods Enzymol. 1986;132:569–585. doi: 10.1016/s0076-6879(86)32042-1. [DOI] [PubMed] [Google Scholar]
  34. Zgliczyński J. M., Stelmaszyńska T., Domański J., Ostrowski W. Chloramines as intermediates of oxidation reaction of amino acids by myeloperoxidase. Biochim Biophys Acta. 1971 Jun 16;235(3):419–424. doi: 10.1016/0005-2744(71)90281-6. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES