Table 2.
ROI | 13 weeks | 24 weeks | 40 weeks | 56 weeks |
---|---|---|---|---|
Total | ||||
Hippocampus | ||||
PSAPP | 378 ± 40 (N = 6) |
427 ± 85 (N = 5) |
462 ± 104 (N = 6) |
410 ± 80 (N = 5) |
CNT | 472 ± 105 (N = 6) |
467 ± 79 (N = 6) |
349 ± 65 (N = 7) |
376 ± 23 (N = 7) |
Dendritic Layer | ||||
PSAPP | 294 ± 33 | 334 ± 68 | 360 ± 83 | 312 ± 59 |
CNT | 366 ± 79 | 370 ± 65 | 270 ± 54 | 297 ± 20 |
PCL | ||||
PSAPP | 374 ± 36 | 401 ± 48 | 438 ± 084 | 411 ± 114 |
CNT | 452 ± 64 | 463 ± 103 | 320 ± 57 | 345 ± 29 |
CA3 | ||||
PSAPP | 752 ± 91 | 814 ± 142 | 950 ± 178 | 868 ± 207 |
CNT | 893 ± 193 | 979 ± 198 | 762 ± 160 | 774 ± 53 |
Hilus | ||||
PSAPP | 1173 ± 161 | 1415 ± 303 | 1700 ± 266* | 1757 ± 540*,# |
CNT | 1497 ± 238 | 1547 ± 393 | 1244 ± 345 | 1150 ± 98 |
Cortex | ||||
PSAPP | 300 ± 30 | 360 ± 110 | 430 ± 180* | 800 ± 200*,# |
CNT | 330 ± 80 | 330 ± 50 | 280 ± 70 | 310 ± 60 |
significantly different from 13 weeks
significantly different from 24 weeks
significantly different from CNT