Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1994 Nov;62(11):5157–5160. doi: 10.1128/iai.62.11.5157-5160.1994

Hypoglycemia and hyperinsulinemia in rodent models of severe malaria infection.

K Elased 1, J H Playfair 1
PMCID: PMC303239  PMID: 7927799

Abstract

Severe hypoglycemia developed during nonlethal Plasmodium chabaudi and lethal P. yoelii blood stage malaria infection in mice, always in association with hyperinsulinemia. Supernatants of lethal P. yoelii incubated overnight induced hypoglycemia and hyperinsulinemia in normal mice. In murine malaria, hypoglycemia may be largely secondary to increased insulin secretion.

Full text

PDF
5157

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adun E. H., Williams J. S., Meroney F. C., Hutt G. Pathophysiology of Plasmodium berghei infection in mice. Exp Parasitol. 1965 Dec;17(3):277–286. doi: 10.1016/0014-4894(65)90071-8. [DOI] [PubMed] [Google Scholar]
  2. Bate C. A., Taverne J., Román E., Moreno C., Playfair J. H. Tumour necrosis factor induction by malaria exoantigens depends upon phospholipid. Immunology. 1992 Jan;75(1):129–135. [PMC free article] [PubMed] [Google Scholar]
  3. Davis T. M., Brown A. E., Smith C. D. Metabolic disturbances in Plasmodium coatneyi-infected rhesus monkeys. Int J Parasitol. 1993 Aug;23(5):557–563. doi: 10.1016/0020-7519(93)90160-z. [DOI] [PubMed] [Google Scholar]
  4. Evans D. A., Jacobs D. O., Wilmore D. W. Tumor necrosis factor enhances glucose uptake by peripheral tissues. Am J Physiol. 1989 Nov;257(5 Pt 2):R1182–R1189. doi: 10.1152/ajpregu.1989.257.5.R1182. [DOI] [PubMed] [Google Scholar]
  5. Feinstein R., Kanety H., Papa M. Z., Lunenfeld B., Karasik A. Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J Biol Chem. 1993 Dec 15;268(35):26055–26058. [PubMed] [Google Scholar]
  6. Grau G. E., Taylor T. E., Molyneux M. E., Wirima J. J., Vassalli P., Hommel M., Lambert P. H. Tumor necrosis factor and disease severity in children with falciparum malaria. N Engl J Med. 1989 Jun 15;320(24):1586–1591. doi: 10.1056/NEJM198906153202404. [DOI] [PubMed] [Google Scholar]
  7. HALES C. N., RANDLE P. J. Immunoassay of insulin with insulin-antibody precipitate. Biochem J. 1963 Jul;88:137–146. doi: 10.1042/bj0880137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Henquin J. C. Quinine and the stimulus-secretion coupling in pancreatic beta-cells: glucose-like effects on potassium permeability and insulin release. Endocrinology. 1982 Apr;110(4):1325–1332. doi: 10.1210/endo-110-4-1325. [DOI] [PubMed] [Google Scholar]
  9. Holloway P. A., Krishna S., White N. J. Plasmodium berghei: lactic acidosis and hypoglycaemia in a rodent model of severe malaria; effects of glucose, quinine, and dichloroacetate. Exp Parasitol. 1991 Feb;72(2):123–133. doi: 10.1016/0014-4894(91)90130-o. [DOI] [PubMed] [Google Scholar]
  10. Looareesuwan S., Phillips R. E., White N. J., Kietinun S., Karbwang J., Rackow C., Turner R. C., Warrell D. A. Quinine and severe falciparum malaria in late pregnancy. Lancet. 1985 Jul 6;2(8445):4–8. doi: 10.1016/s0140-6736(85)90056-x. [DOI] [PubMed] [Google Scholar]
  11. Phillips R. E., Looareesuwan S., Molyneux M. E., Hatz C., Warrell D. A. Hypoglycaemia and counterregulatory hormone responses in severe falciparum malaria: treatment with Sandostatin. Q J Med. 1993 Apr;86(4):233–240. [PubMed] [Google Scholar]
  12. Schofield L., Hackett F. Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites. J Exp Med. 1993 Jan 1;177(1):145–153. doi: 10.1084/jem.177.1.145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Sidey F. M., Wardlaw A. C., Furman B. L. Hypoglycaemia and acute stress-induced hyperinsulinaemia in mice infected with Bordetella pertussis or treated with pertussis toxin. J Endocrinol. 1987 Jan;112(1):113–122. doi: 10.1677/joe.0.1120113. [DOI] [PubMed] [Google Scholar]
  14. Taylor K., Bate C. A., Carr R. E., Butcher G. A., Taverne J., Playfair J. H. Phospholipid-containing toxic malaria antigens induce hypoglycaemia. Clin Exp Immunol. 1992 Oct;90(1):1–5. doi: 10.1111/j.1365-2249.1992.tb05822.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Taylor K., Carr R., Playfair J. H., Saggerson E. D. Malarial toxic antigens synergistically enhance insulin signalling. FEBS Lett. 1992 Oct 26;311(3):231–234. doi: 10.1016/0014-5793(92)81109-y. [DOI] [PubMed] [Google Scholar]
  16. Taylor T. E., Molyneux M. E., Wirima J. J., Fletcher K. A., Morris K. Blood glucose levels in Malawian children before and during the administration of intravenous quinine for severe falciparum malaria. N Engl J Med. 1988 Oct 20;319(16):1040–1047. doi: 10.1056/NEJM198810203191602. [DOI] [PubMed] [Google Scholar]
  17. Vlassara H., Brownlee M., Cerami A. Specific macrophage receptor activity for advanced glycosylation end products inversely correlates with insulin levels in vivo. Diabetes. 1988 Apr;37(4):456–461. doi: 10.2337/diab.37.4.456. [DOI] [PubMed] [Google Scholar]
  18. White N. J., Warrell D. A., Chanthavanich P., Looareesuwan S., Warrell M. J., Krishna S., Williamson D. H., Turner R. C. Severe hypoglycemia and hyperinsulinemia in falciparum malaria. N Engl J Med. 1983 Jul 14;309(2):61–66. doi: 10.1056/NEJM198307143090201. [DOI] [PubMed] [Google Scholar]
  19. Yelich M. R., Filkins J. P. Mechanism of hyperinsulinemia in endotoxicosis. Am J Physiol. 1980 Aug;239(2):E156–E161. doi: 10.1152/ajpendo.1980.239.2.E156. [DOI] [PubMed] [Google Scholar]
  20. Yoshida T., Nakamura Y., Nakano K., Kondo M. Effect of islet-activating protein (IAP), purified from the culture medium of Bordetella pertussis, on the secretion of immunoreactive insulin and glucagon in normal, alloxan-treated, and depancreatized dogs. Diabetes. 1981 May;30(5):430–434. doi: 10.2337/diab.30.5.430. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES