Table 1.
Clinical and biochemical characteristics and whole blood cytokine stimulation of obese and non-obese women at baseline and at six months post-surgery in the obese women
| Variable | Obese Baselinea (n=17) |
Non-obese Baselinea (n=19) |
Obese Six-months Post-surgerya (n=17) |
|---|---|---|---|
| BMI (kg/m2)b,d | 46.6 (7.9) | 22.5 (3.0)f | 37.6 (5.5)g |
| Waist circumference (cm)b,d | 128.2 (17.6) | 78.5(6.7) f | 114.5 (15.6) g |
| Serum IL-6 (pg/mL)c,d | 2.85 (1.18) | 2.44 (2.11) | 1.66 (0.95) g |
| hs-CRP (mg/L)c,d | 11.88 (5.53) | 0.91 (1.45) f | 6.67 (4.77) g |
| HOMA-IR c,e | 4.97 (3.72) | 1.44 (0.66) f | 2.62 (2.08) g |
| Hemoglobin (g/dL) b,d | 12.1 (1.14) | 12.1 (0.9) | 13.0 (1.1) g |
| Serum Hepcidin (ng/mL)c,d | 123.27 (84.76) | 22.56 (1.30) f | 31.64 (23.69) g |
| sTfR (nmol/L)b,e | 33.17 (11.66) | 28.57 (13.88) | 24.28 (6.44) g |
| IL-6 (pg/mL) (control)c,e | 312.85 (473.46) | 302.03 (369.06) | 864.33 (489.93) g |
| IL-6 LPS (pg/mL) b,d | 8288.56 (3606.74) | 11999.55 (2881.20) f | 12071.76 (4073) g |
| IL-6 ZY (pg/mL)b,d | 7320.40 (5054.52) | 11000.62 (3712.67) f | 11846.70 (4888) g |
| IL-10 (pg/mL) (control)c,e | 477.70 (368.57) | 470.64 (313.81) | 473.95 (356.49) |
| IL-10 LPS (pg/mL) b,d | 4375.09 (2369.51) | 5242.83 (1828.11) | 4438.09 (2058) |
| IL-10 ZY (pg/mL) b,d | 4870.36 (2434.49) | 4886.55 (2114.54) | 4073.43 (2256) |
| IL-22 (pg/mL) (control)c,e | 132.96 (88.61) | 96.26 (50.99) | 160.79 (175.84) |
| IL-22 LPS (pg/mL) b,e | 501.96 (196.75) | 343.09 (125.07) f | 563.62 (520.18) |
| IL-22 ZY (pg/mL)c,e | 469.65 (145.97) | 361.59 (154.77) f | 647.28 (770.18) |
| IFNγ (pg/mL) (control)c,e | 365.27 (305.51) | 985.41 (351.05) f | 426.68 (410.79) |
| IFNγ LPS (pg/mL)c,e | 798.94 (812.58) | 2526.84 (637.71) f | 1053.22 (1190) |
| IFNγ ZY (pg/mL)c,e | 771.71 (745.92) | 2403.96 (741.70) f | 976.33 (1146) |
| TNFα (pg/mL) (control) b,d | 14.00 (6.83) | 12.27 (8.34) | 19.74 (10.56) |
| TNFα LPS (pg/mL) b,d | 63.59 (25.04) | 110.60 (62.50) f | 161.47 (123.29) g |
| TNFα ZY (pg/mL) b,e | 51.05 (23.56) | 92.32 (55.81) f | 109.21 (76.79) g |
Values are mean (± standard deviation)
T-test was used for comparison of obese versus non-obese women at baseline
Wilcoxon rank sum (non-parametric test) was used for comparison of obese versus non-obese women at baseline
Paired t-test was used for comparison of baseline and follow-up values in the obese women
Wilcoxon signed rank (non-parametric test) was used for comparison of baseline and follow-up values in the obese women
denotes p<0.025 (correction factor= 0.05/2 groups) for comparison between obese vs. non-obese women at baseline
denotes p<0.025 (correction factor= 0.05/2 groups) for comparison between obese at baseline vs. six months post-restrictive bariatric surgery
Abbreviations: BMI, body mass index; IL-6, interleukin-6; hs-CRP, high sensitivity C reactive protein; HOMA-IR, homeostasis model assessment of insulin resistance; sTfR, serum transferring receptor; control, unstimulated whole blood culture, ; LPS, lipopolysacchride; ZY, zymosan; IL-10, interleukin-10; IL-22, interleukin-22; IFNγ, interferon gamma; TNFα, tumor necrosis alpha