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American Journal of Alzheimer's Disease and Other Dementias logoLink to American Journal of Alzheimer's Disease and Other Dementias
. 2010 Aug;25(5):425–431. doi: 10.1177/1533317510367636

Upper and Lower Extremity Motor Performance and Functional Impairment in Alzheimer’s Disease

Liesi E Hebert 1, Julia L Bienias, Judith J McCann 2, Paul A Scherr 3, Robert S Wilson 4, Denis A Evans 5
PMCID: PMC3033748  NIHMSID: NIHMS264869  PMID: 20484749

Abstract

This report examines the relation of upper and lower extremity motor performance to functional impairment among 371 persons with probable Alzheimer’s disease (AD). Cognitive and motor performance tests were administered at 6-month intervals for up to 4 years. Motor performance was assessed using 3 lower extremity tests and 2 upper extremity tests. Functional impairment was measured at 3-month intervals using caregiver ratings of impairments in activities of daily living, mobility, and range of motion. Both lower and upper extremity performance were inversely related to functional impairments on all 3 scales (all Ps < .001), after controlling for age, sex, and level of cognitive impairment. This suggests that motor performance contributes to functional impairments in AD, independent of cognitive impairment. It is important to preserve motor performance in individuals with AD because it influences physical function throughout the course of the disease.

Keywords: Alzheimer’s disease, physical function, physical performance, longitudinal study

Full Text

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Contributor Information

Liesi E. Hebert, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA, Liesi_Hebert@rush.edu, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.

Judith J. McCann, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA, College of Nursing, Rush University Medical Center, Chicago, IL, USA.

Paul A. Scherr, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Robert S. Wilson, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA, Department of Behavorial Sciences, Rush University Medical Center, Chicago, IL, USA, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

Denis A. Evans, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.

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