Table 3. Pathological and cytogenetic details of 80 patients with World Health Organization (WHO)-defined ‘myelodysplastic syndrome with isolated del(5q)'.
| Pathological and cytogenetic variable | Numbera |
|---|---|
| Dyserythropoiesis (%) | 28 (35) |
| Dysgranulopoiesis (%) | 16 (20) |
| Dysmegakaryopoiesis (%) | 69 (86) |
| Dysplasia affecting a single cell line (%) | 36 (45) |
| Dysplasia affecting two cell lines (%) | 27 (34) |
| Dysplasia affecting all three cell lines (%) | 6 (7) |
| Abnormal metaphases with isolated del(5q) (median, range) | 13 (2–26) |
| 5q breakpoints (%) | |
| 5q13q22 | 2 (2) |
| 5q13q33 | 51(57) |
| 5q15q31 | 3 (3) |
| 5q15q33 | 21 (24) |
| 5q22q31 | 4 (5) |
| 5q22q33 | 4 (5) |
| 5q22q35 | 3 (3) |
a
Please note that bone marrow and peripheral smears were available for pathological re-review in 80 patients; cytogenetic information was available for re-review in 88 patients. Seven patients had no overt evidence of myelodysplasia.