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. 1989 Jan;83(1):326–330. doi: 10.1172/JCI113878

Evidence that insulin-like growth factor I increases renal plasma flow and glomerular filtration rate in fasted rats.

R Hirschberg 1, J D Kopple 1
PMCID: PMC303679  PMID: 2910916

Abstract

The mechanisms whereby growth hormone may increase renal plasma flow (RPF) and GFR are not known, but circumstantial evidence has implicated insulin-like growth factor I (IGF-I) as a mediator of this effect. This study examined whether an infusion of IGF-I will increase RPF and GFR, whether this effect occurs quickly, and if this effect is dependent on eicosanoids or peptide hormones known to affect renal function. Rats fasted for 3 d to reduce IGF-I and IGF-I plasma binding proteins were anesthetized; then the rats received an intravenous injection of 25 micrograms/kg IGF-I, and an infusion of 25 micrograms/kg IGF-I within 20 min. Controls received infusion of the vehicle. RPF (para-aminohippurate clearances), GFR (inulin clearances), renal vascular resistance (RVR), mean arterial blood pressure (MABP), plasma IGF-I, and glucose concentrations were measured repeatedly. At the end of the 20-min infusion, plasma IGF-I tended to be increased in the animals that received IGF-I (P = 0.069), but did not increase in the control rats. IGF-I induced a significant and sustained fall in RVR and rise in RPF and GFR without any change in MABP. A small, transient, but significant decrease in plasma glucose concentrations was observed during IGF-I but not during vehicle infusion. Indomethacin, but not somatostatin, blocked the renal response to IGF-I infusion. Thus, IGF-I infusion increases RPF and GFR and reduces RVR in fasted rats. This effect requires the presence of eicosanoids but does not seem to require other peptide hormones suppressed by somatostatin.

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Selected References

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  1. Castellino P., Coda B., DeFronzo R. A. Effect of amino acid infusion on renal hemodynamics in humans. Am J Physiol. 1986 Jul;251(1 Pt 2):F132–F140. doi: 10.1152/ajprenal.1986.251.1.F132. [DOI] [PubMed] [Google Scholar]
  2. Christiansen J. S., Gammelgaard J., Orskov H., Andersen A. R., Telmer S., Parving H. H. Kidney function and size in normal subjects before and during growth hormone administration for one week. Eur J Clin Invest. 1981 Dec;11(6):487–490. doi: 10.1111/j.1365-2362.1981.tb02018.x. [DOI] [PubMed] [Google Scholar]
  3. Clemmons D. R., Underwood L. E., Dickerson R. N., Brown R. O., Hak L. J., MacPhee R. D., Heizer W. D. Use of plasma somatomedin-C/insulin-like growth factor I measurements to monitor the response to nutritional repletion in malnourished patients. Am J Clin Nutr. 1985 Feb;41(2):191–198. doi: 10.1093/ajcn/41.2.191. [DOI] [PubMed] [Google Scholar]
  4. Conti F. G., Striker L. J., Lesniak M. A., MacKay K., Roth J., Striker G. E. Studies on binding and mitogenic effect of insulin and insulin-like growth factor I in glomerular mesangial cells. Endocrinology. 1988 Jun;122(6):2788–2795. doi: 10.1210/endo-122-6-2788. [DOI] [PubMed] [Google Scholar]
  5. D'Ercole A. J., Stiles A. D., Underwood L. E. Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action. Proc Natl Acad Sci U S A. 1984 Feb;81(3):935–939. doi: 10.1073/pnas.81.3.935. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. FALKHEDEN T., WICKBOM I. RENAL FUNCTION AND KIDNEY SIZE FOLLOWING HYPOPHYSECTOMY IN MAN. Acta Endocrinol (Copenh) 1965 Mar;48:348–354. doi: 10.1530/acta.0.0480348. [DOI] [PubMed] [Google Scholar]
  7. Guler H. P., Zapf J., Froesch E. R. Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults. N Engl J Med. 1987 Jul 16;317(3):137–140. doi: 10.1056/NEJM198707163170303. [DOI] [PubMed] [Google Scholar]
  8. Hirschberg R. R., Kopple J. D. Increase in renal plasma flow and glomerular filtration rate during growth hormone treatment may be mediated by insulin-like growth factor I. Am J Nephrol. 1988;8(3):249–254. doi: 10.1159/000167592. [DOI] [PubMed] [Google Scholar]
  9. Hirschberg R. R., Zipser R. D., Slomowitz L. A., Kopple J. D. Glucagon and prostaglandins are mediators of amino acid-induced rise in renal hemodynamics. Kidney Int. 1988 Jun;33(6):1147–1155. doi: 10.1038/ki.1988.123. [DOI] [PubMed] [Google Scholar]
  10. Ichikawa I., Purkerson M. L., Klahr S., Troy J. L., Martinez-Maldonado M., Brenner B. M. Mechanism of reduced glomerular filtration rate in chronic malnutrition. J Clin Invest. 1980 May;65(5):982–988. doi: 10.1172/JCI109784. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Isley W. L., Underwood L. E., Clemmons D. R. Dietary components that regulate serum somatomedin-C concentrations in humans. J Clin Invest. 1983 Feb;71(2):175–182. doi: 10.1172/JCI110757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Klahr S., Alleyne G. A. Effects of chronic protein-calorie malnutrition on the kidney. Kidney Int. 1973 Mar;3(3):129–141. doi: 10.1038/ki.1973.21. [DOI] [PubMed] [Google Scholar]
  13. Levine L., Xiao D. M., Fujiki H. Combinations of palytoxin or 12-O-tetradecanoylphorbol-13-acetate and recombinant human insulin growth factor-I or insulin synergistically stimulate prostaglandin production in cultured rat liver cells and squirrel monkey aorta smooth muscle cells. Prostaglandins. 1986 Apr;31(4):669–681. doi: 10.1016/0090-6980(86)90173-5. [DOI] [PubMed] [Google Scholar]
  14. Miyakawa M., Hizuka N., Takano K., Tanaka I., Horikawa R., Honda N., Shizume K. Radioimmunoassay for insulin-like growth factor I (IGF-I) using biosynthetic IGF-I. Endocrinol Jpn. 1986 Dec;33(6):795–801. doi: 10.1507/endocrj1954.33.795. [DOI] [PubMed] [Google Scholar]
  15. Phillips L. S., Unterman T. G. Somatomedin activity in disorders of nutrition and metabolism. Clin Endocrinol Metab. 1984 Mar;13(1):145–189. doi: 10.1016/s0300-595x(84)80012-2. [DOI] [PubMed] [Google Scholar]
  16. Reichlin S. Somatostatin (second of two parts). N Engl J Med. 1983 Dec 22;309(25):1556–1563. doi: 10.1056/NEJM198312223092506. [DOI] [PubMed] [Google Scholar]
  17. Underwood L. E., D'Ercole A. J., Clemmons D. R., Van Wyk J. J. Paracrine functions of somatomedins. Clin Endocrinol Metab. 1986 Feb;15(1):59–77. doi: 10.1016/s0300-595x(86)80042-1. [DOI] [PubMed] [Google Scholar]
  18. Zapf J., Hauri C., Waldvogel M., Froesch E. R. Acute metabolic effects and half-lives of intravenously administered insulinlike growth factors I and II in normal and hypophysectomized rats. J Clin Invest. 1986 Jun;77(6):1768–1775. doi: 10.1172/JCI112500. [DOI] [PMC free article] [PubMed] [Google Scholar]

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