Table III.
Sex-, age-, and BMI-adjusted Mortality Hazard Ratios and corresponding 95% Confidence Intervals associated with the six longitudinal spirometric patterns. Total N is 1325 because 43 subjects had missing information for BMI.
| Underlying Cause of Death |
|||||||
|---|---|---|---|---|---|---|---|
| Longitudinal Spirometric Patterns | All-cause adjHR (95 CI) | Heart Disease adjHR (95% CI) | Cancer adjHR (95% CI) | Lung Cancer adjHR (95% CI) | COPD adjHR (95% CI) | Stroke adjHR (95% CI) | Diabetes adjHR (95% CI) |
| Consistent Normal (N = 883) | reference | reference | reference | reference | reference | reference | reference |
| Recurrent Restrictive (N = 65) | 1.7 (1.3 – 2.3) | 2.0 (1.3 – 3.1) | 1.0 (0.5 – 2.2) | 0.7 (0.1 – 5.5) | 2.0 (0.2 – 17.3) | 2.4 (0.9 – 6.3) | 8.0 (2.9 – 21.8) |
| Inconsistent Restrictive (N = 60) | 1.9 (1.4 – 2.6) | 2.7 (1.7 – 4.3) | 1.4 (0.7 – 3.0) | 1.5 (0.4 – 6.6) | N/A | 3.5 (1.2 – 9.8) | 6.0 (1.9 – 19.2) |
| Recurrent Obstructive (N = 153) | 2.4 (1.9 – 2.9) | 2.1 (1.4 – 3.0) | 1.4 (0.8 – 2.2) | 3.2 (1.5 – 6.6) | 38.0 (15.6 – 92.6) | 6.2 (2.9 – 13.4) | 5.4 (2.0 – 15.2) |
| Inconsistent Obstructive (N = 52) | 1.2 (0.8 – 1.7) | 1.3 (0.8 – 2.3) | 0.7 (0.3 – 1.8) | N/A | 4.2 (0.8 – 21.1) | 1.5 (0.3 – 6.5) | 1.0 (0.1 – 7.7) |
| Mixed Restrict/Obstruct (N = 112) | 1.4 (1.1 – 1.8) | 1.6 (1.1 – 2.3) | 0.7 (0.3 – 1.3) | 1.1 (0.4 – 3.4) | 10.9 (4.0 – 30.0) | 1.0 (0.3 – 3.0) | 4.7 (1.9 – 11.9) |
| N events | 728 | 268 | 141 | 45 | 61 | 48 | 38* |
*
Because only 10 subjects had diabetes identified as underlying cause of death, in Cox models for diabetes mortality events were defined as “deaths with diabetes indicated as either underlying cause of death or co-existing condition on the death certificate”.