Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1989 Feb;83(2):355–361. doi: 10.1172/JCI113891

Function and heterogeneity of human Fc receptors for immunoglobulin G.

J C Unkeless 1
PMCID: PMC303688  PMID: 2643627

Full text

PDF
355

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akiyama Y., Lubeck M. D., Steplewski Z., Koprowski H. Induction of mouse IgG2a- and IgG3-dependent cellular cytotoxicity in human monocytic cells (U937) by immune interferon. Cancer Res. 1984 Nov;44(11):5127–5131. [PubMed] [Google Scholar]
  2. Anasetti C., Martin P. J., June C. H., Hellstrom K. E., Ledbetter J. A., Rabinovitch P. S., Morishita Y., Hellstrom I., Hansen J. A. Induction of calcium flux and enhancement of cytolytic activity in natural killer cells by cross-linking of the sheep erythrocyte binding protein (CD2) and the Fc-receptor (CD16). J Immunol. 1987 Sep 15;139(6):1772–1779. [PubMed] [Google Scholar]
  3. Anderson C. L., Guyre P. M., Whitin J. C., Ryan D. H., Looney R. J., Fanger M. W. Monoclonal antibodies to Fc receptors for IgG on human mononuclear phagocytes. Antibody characterization and induction of superoxide production in a monocyte cell line. J Biol Chem. 1986 Sep 25;261(27):12856–12864. [PubMed] [Google Scholar]
  4. Anderson C. L. Isolation of the receptor for IgG from a human monocyte cell line (U937) and from human peripheral blood monocytes. J Exp Med. 1982 Dec 1;156(6):1794–1806. doi: 10.1084/jem.156.6.1794. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Anderson C. L., Ryan D. H., Looney R. J., Leary P. C. Structural polymorphism of the human monocyte 40 kilodalton Fc receptor for IgG. J Immunol. 1987 Apr 1;138(7):2254–2256. [PubMed] [Google Scholar]
  6. Anegón I., Cuturi M. C., Trinchieri G., Perussia B. Interaction of Fc receptor (CD16) ligands induces transcription of interleukin 2 receptor (CD25) and lymphokine genes and expression of their products in human natural killer cells. J Exp Med. 1988 Feb 1;167(2):452–472. doi: 10.1084/jem.167.2.452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Berken A., Benacerraf B. Properties of antibodies cytophilic for macrophages. J Exp Med. 1966 Jan 1;123(1):119–144. doi: 10.1084/jem.123.1.119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Blackburn W. D., Jr, Heck L. W., Koopman W. J., Gresham H. D. A low molecular weight, heat-labile factor enhances neutrophil Fc receptor-mediated lysosomal enzyme release and phagocytosis. Arthritis Rheum. 1987 Sep;30(9):1006–1014. doi: 10.1002/art.1780300907. [DOI] [PubMed] [Google Scholar]
  9. Brozna J. P., Hauff N. F., Phillips W. A., Johnston R. B., Jr Activation of the respiratory burst in macrophages. Phosphorylation specifically associated with Fc receptor-mediated stimulation. J Immunol. 1988 Sep 1;141(5):1642–1647. [PubMed] [Google Scholar]
  10. Ceuppens J. L., Van Vaeck F. Direct demonstration of binding of anti-Leu 4 antibody to the 40 kDa Fc receptor on monocytes as a prerequisite for anti-Leu 4-induced T cell mitogenesis. J Immunol. 1987 Dec 15;139(12):4067–4071. [PubMed] [Google Scholar]
  11. Clarkson S. B., Bussel J. B., Kimberly R. P., Valinsky J. E., Nachman R. L., Unkeless J. C. Treatment of refractory immune thrombocytopenic purpura with an anti-Fc gamma-receptor antibody. N Engl J Med. 1986 May 8;314(19):1236–1239. doi: 10.1056/NEJM198605083141907. [DOI] [PubMed] [Google Scholar]
  12. Clarkson S. B., Kimberly R. P., Valinsky J. E., Witmer M. D., Bussel J. B., Nachman R. L., Unkeless J. C. Blockade of clearance of immune complexes by an anti-Fc gamma receptor monoclonal antibody. J Exp Med. 1986 Aug 1;164(2):474–489. doi: 10.1084/jem.164.2.474. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Clarkson S. B., Ory P. A. CD16. Developmentally regulated IgG Fc receptors on cultured human monocytes. J Exp Med. 1988 Feb 1;167(2):408–420. doi: 10.1084/jem.167.2.408. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Clement L. T., Tilden A. B., Dunlap N. E. Analysis of the monocyte Fc receptors and antibody-mediated cellular interactions required for the induction of T cell proliferation by anti-T3 antibodies. J Immunol. 1985 Jul;135(1):165–171. [PubMed] [Google Scholar]
  15. Di Virgilio F., Meyer B. C., Greenberg S., Silverstein S. C. Fc receptor-mediated phagocytosis occurs in macrophages at exceedingly low cytosolic Ca2+ levels. J Cell Biol. 1988 Mar;106(3):657–666. doi: 10.1083/jcb.106.3.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Diamond B., Boccumini L., Birshtein B. K. Site of binding of IgG2b and IgG2a by mouse macrophage Fc receptors by using cyanogen bromide fragments. J Immunol. 1985 Feb;134(2):1080–1083. [PubMed] [Google Scholar]
  17. Dickler H. B. Lymphocyte receptors for immunoglobulin. Adv Immunol. 1976;24:167–214. doi: 10.1016/s0065-2776(08)60330-2. [DOI] [PubMed] [Google Scholar]
  18. Dougherty G. J., Selvendran Y., Murdoch S., Palmer D. G., Hogg N. The human mononuclear phagocyte high-affinity Fc receptor, FcRI, defined by a monoclonal antibody, 10.1. Eur J Immunol. 1987 Oct;17(10):1453–1459. doi: 10.1002/eji.1830171011. [DOI] [PubMed] [Google Scholar]
  19. Duncan A. R., Woof J. M., Partridge L. J., Burton D. R., Winter G. Localization of the binding site for the human high-affinity Fc receptor on IgG. Nature. 1988 Apr 7;332(6164):563–564. doi: 10.1038/332563a0. [DOI] [PubMed] [Google Scholar]
  20. Egawa S. E., Abo T., Hiwatashi N. Enhancement of human natural killer activity by the monoclonal Leu-11 antibodies. Cell Immunol. 1987 Feb;104(2):386–399. doi: 10.1016/0008-8749(87)90040-2. [DOI] [PubMed] [Google Scholar]
  21. Feister A. J., Browder B., Willis H. E., Mohanakumar T., Ruddy S. Pertussis toxin inhibits human neutrophil responses mediated by the 42-kilodalton IgG Fc receptor. J Immunol. 1988 Jul 1;141(1):228–233. [PubMed] [Google Scholar]
  22. Fleit H. B., Wright S. D., Durie C. J., Valinsky J. E., Unkeless J. C. Ontogeny of Fc receptors and complement receptor (CR3) during human myeloid differentiation. J Clin Invest. 1984 Feb;73(2):516–525. doi: 10.1172/JCI111238. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Fleit H. B., Wright S. D., Unkeless J. C. Human neutrophil Fc gamma receptor distribution and structure. Proc Natl Acad Sci U S A. 1982 May;79(10):3275–3279. doi: 10.1073/pnas.79.10.3275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Frey J., Engelhardt W. Characterization and structural analysis of Fc gamma receptors of human monocytes, a monoblast cell line (U937) and a myeloblast cell line (HL-60) by a monoclonal antibody. Eur J Immunol. 1987 May;17(5):583–591. doi: 10.1002/eji.1830170502. [DOI] [PubMed] [Google Scholar]
  25. Gergely J., Sármay G., Rozsnyay Z., Stanworth D. R., Klein E. Binding characteristics and isotype specificity of Fc receptors on K cells. Mol Immunol. 1986 Nov;23(11):1203–1209. doi: 10.1016/0161-5890(86)90152-5. [DOI] [PubMed] [Google Scholar]
  26. Gidlund M., Rossi P., Cotran P., Ramstedt U., Wigzell H. In human monocytes a strong correlation exists between expression of the M3 antigen, Fc-mediated phagocytic activity and failure to participate in extracellular antibody-dependent cytotoxicity. Eur J Immunol. 1988 Mar;18(3):477–480. doi: 10.1002/eji.1830180324. [DOI] [PubMed] [Google Scholar]
  27. Girard M. T., Hjaltadottir S., Fejes-Toth A. N., Guyre P. M. Glucocorticoids enhance the gamma-interferon augmentation of human monocyte immunoglobulin G Fc receptor expression. J Immunol. 1987 May 15;138(10):3235–3241. [PubMed] [Google Scholar]
  28. Goroff D. K., Finkelman F. D. Activation of B cells in vivo by a Fab/Fc fragment of a monoclonal anti-IgD antibody requires an interaction between the antibody fragment and a cellular IgG Fc receptor. J Immunol. 1988 May 1;140(9):2919–2924. [PubMed] [Google Scholar]
  29. Graziano R. F., Fanger M. W. Fc gamma RI and Fc gamma RII on monocytes and granulocytes are cytotoxic trigger molecules for tumor cells. J Immunol. 1987 Nov 15;139(10):3536–3541. [PubMed] [Google Scholar]
  30. Gresham H. D., Clement L. T., Volanakis J. E., Brown E. J. Cholera toxin and pertussis toxin regulate the Fc receptor-mediated phagocytic response of human neutrophils in a manner analogous to regulation by monoclonal antibody 1C2. J Immunol. 1987 Dec 15;139(12):4159–4166. [PubMed] [Google Scholar]
  31. Guyre P. M., Morganelli P. M., Miller R. Recombinant immune interferon increases immunoglobulin G Fc receptors on cultured human mononuclear phagocytes. J Clin Invest. 1983 Jul;72(1):393–397. doi: 10.1172/JCI110980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Hibbs M. L., Bonadonna L., Scott B. M., McKenzie I. F., Hogarth P. M. Molecular cloning of a human immunoglobulin G Fc receptor. Proc Natl Acad Sci U S A. 1988 Apr;85(7):2240–2244. doi: 10.1073/pnas.85.7.2240. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Hibbs M. L., Classon B. J., Walker I. D., McKenzie I. F., Hogarth P. M. The structure of the murine Fc receptor for IgG. Assignment of intrachain disulfide bonds, identification of N-linked glycosylation sites, and evidence for a fourth form of Fc receptor. J Immunol. 1988 Jan 15;140(2):544–550. [PubMed] [Google Scholar]
  34. Hibbs M. L., Walker I. D., Kirszbaum L., Pietersz G. A., Deacon N. J., Chambers G. W., McKenzie I. F., Hogarth P. M. The murine Fc receptor for immunoglobulin: purification, partial amino acid sequence, and isolation of cDNA clones. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6980–6984. doi: 10.1073/pnas.83.18.6980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Hogarth P. M., Hibbs M. L., Bonadonna L., Scott B. M., Witort E., Pietersz G. A., McKenzie I. F. The mouse Fc receptor for IgG (Ly-17): molecular cloning and specificity. Immunogenetics. 1987;26(3):161–168. doi: 10.1007/BF00365906. [DOI] [PubMed] [Google Scholar]
  36. Huber H., Douglas S. D., Nusbacher J., Kochwa S., Rosenfield R. E. IgG subclass specificity of human monocyte receptor sites. Nature. 1971 Feb 5;229(5284):419–420. doi: 10.1038/229419a0. [DOI] [PubMed] [Google Scholar]
  37. Huizinga T. W., van der Schoot C. E., Jost C., Klaassen R., Kleijer M., von dem Borne A. E., Roos D., Tetteroo P. A. The PI-linked receptor FcRIII is released on stimulation of neutrophils. Nature. 1988 Jun 16;333(6174):667–669. doi: 10.1038/333667a0. [DOI] [PubMed] [Google Scholar]
  38. Jones D. H., Looney R. J., Anderson C. L. Two distinct classes of IgG Fc receptors on a human monocyte line (U937) defined by differences in binding of murine IgG subclasses at low ionic strength. J Immunol. 1985 Nov;135(5):3348–3353. [PubMed] [Google Scholar]
  39. Kinet J. P., Metzger H., Hakimi J., Kochan J. A cDNA presumptively coding for the alpha subunit of the receptor with high affinity for immunoglobulin E. Biochemistry. 1987 Jul 28;26(15):4605–4610. doi: 10.1021/bi00389a002. [DOI] [PubMed] [Google Scholar]
  40. Lew D. P., Andersson T., Hed J., Di Virgilio F., Pozzan T., Stendahl O. Ca2+-dependent and Ca2+-independent phagocytosis in human neutrophils. Nature. 1985 Jun 6;315(6019):509–511. doi: 10.1038/315509a0. [DOI] [PubMed] [Google Scholar]
  41. Lewis V. A., Koch T., Plutner H., Mellman I. A complementary DNA clone for a macrophage-lymphocyte Fc receptor. 1986 Nov 27-Dec 3Nature. 324(6095):372–375. doi: 10.1038/324372a0. [DOI] [PubMed] [Google Scholar]
  42. Looney R. J., Abraham G. N., Anderson C. L. Human monocytes and U937 cells bear two distinct Fc receptors for IgG. J Immunol. 1986 Mar 1;136(5):1641–1647. [PubMed] [Google Scholar]
  43. Looney R. J., Ryan D. H., Takahashi K., Fleit H. B., Cohen H. J., Abraham G. N., Anderson C. L. Identification of a second class of IgG Fc receptors on human neutrophils. A 40 kilodalton molecule also found on eosinophils. J Exp Med. 1986 Apr 1;163(4):826–836. doi: 10.1084/jem.163.4.826. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Peltz G. A., Trounstine M. L., Moore K. W. Cloned and expressed human Fc receptor for IgG mediates anti-CD3-dependent lymphoproliferation. J Immunol. 1988 Sep 15;141(6):1891–1896. [PubMed] [Google Scholar]
  45. Peltz G., Frederick K., Anderson C. L., Peterlin B. M. Characterization of the human monocyte high affinity Fc receptor (hu FcRI). Mol Immunol. 1988 Mar;25(3):243–250. doi: 10.1016/0161-5890(88)90015-6. [DOI] [PubMed] [Google Scholar]
  46. Perussia B., Dayton E. T., Lazarus R., Fanning V., Trinchieri G. Immune interferon induces the receptor for monomeric IgG1 on human monocytic and myeloid cells. J Exp Med. 1983 Oct 1;158(4):1092–1113. doi: 10.1084/jem.158.4.1092. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Perussia B., Trinchieri G. Antibody 3G8, specific for the human neutrophil Fc receptor, reacts with natural killer cells. J Immunol. 1984 Mar;132(3):1410–1415. [PubMed] [Google Scholar]
  48. Petroni K. C., Shen L., Guyre P. M. Modulation of human polymorphonuclear leukocyte IgG Fc receptors and Fc receptor-mediated functions by IFN-gamma and glucocorticoids. J Immunol. 1988 May 15;140(10):3467–3472. [PubMed] [Google Scholar]
  49. Phillips N. E., Parker D. C. Cross-linking of B lymphocyte Fc gamma receptors and membrane immunoglobulin inhibits anti-immunoglobulin-induced blastogenesis. J Immunol. 1984 Feb;132(2):627–632. [PubMed] [Google Scholar]
  50. Phillips N. E., Parker D. C. Subclass specificity of Fc gamma receptor-mediated inhibition of mouse B cell activation. J Immunol. 1985 May;134(5):2835–2838. [PubMed] [Google Scholar]
  51. Qu Z. X., Odin J., Glass J. D., Unkeless J. C. Expression and characterization of a truncated murine Fc gamma receptor. J Exp Med. 1988 Mar 1;167(3):1195–1210. doi: 10.1084/jem.167.3.1195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Ravetch J. V., Luster A. D., Weinshank R., Kochan J., Pavlovec A., Portnoy D. A., Hulmes J., Pan Y. C., Unkeless J. C. Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors. Science. 1986 Nov 7;234(4777):718–725. doi: 10.1126/science.2946078. [DOI] [PubMed] [Google Scholar]
  53. Rosenfeld S. I., Looney R. J., Leddy J. P., Phipps D. C., Abraham G. N., Anderson C. L. Human platelet Fc receptor for immunoglobulin G. Identification as a 40,000-molecular-weight membrane protein shared by monocytes. J Clin Invest. 1985 Dec;76(6):2317–2322. doi: 10.1172/JCI112242. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Rosenfeld S. I., Ryan D. H., Looney R. J., Anderson C. L., Abraham G. N., Leddy J. P. Human Fc gamma receptors: stable inter-donor variation in quantitative expression on platelets correlates with functional responses. J Immunol. 1987 May 1;138(9):2869–2873. [PubMed] [Google Scholar]
  55. Schreiber R. D. Identification of gamma-interferon as a murine macrophage-activating factor for tumor cytotoxicity. Contemp Top Immunobiol. 1984;13:171–198. doi: 10.1007/978-1-4757-1445-6_9. [DOI] [PubMed] [Google Scholar]
  56. Selvaraj P., Rosse W. F., Silber R., Springer T. A. The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal haemoglobinuria. Nature. 1988 Jun 9;333(6173):565–567. doi: 10.1038/333565a0. [DOI] [PubMed] [Google Scholar]
  57. Shen L., Guyre P. M., Anderson C. L., Fanger M. W. Heteroantibody-mediated cytotoxicity: antibody to the high affinity Fc receptor for IgG mediates cytotoxicity by human monocytes that is enhanced by interferon-gamma and is not blocked by human IgG. J Immunol. 1986 Dec 1;137(11):3378–3382. [PubMed] [Google Scholar]
  58. Shen L., Guyre P. M., Fanger M. W. Polymorphonuclear leukocyte function triggered through the high affinity Fc receptor for monomeric IgG. J Immunol. 1987 Jul 15;139(2):534–538. [PubMed] [Google Scholar]
  59. Shimizu A., Tepler I., Benfey P. N., Berenstein E. H., Siraganian R. P., Leder P. Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1907–1911. doi: 10.1073/pnas.85.6.1907. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Simmons D., Seed B. The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein. Nature. 1988 Jun 9;333(6173):568–570. doi: 10.1038/333568a0. [DOI] [PubMed] [Google Scholar]
  61. Spiegelberg H. L., Perlmann H., Perlmann P. Interaction of K lymphocytes with myeloma proteins of different IgG subclasses. J Immunol. 1976 Nov;117(5 Pt 1):1464–1471. [PubMed] [Google Scholar]
  62. Stengelin S., Stamenkovic I., Seed B. Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning. EMBO J. 1988 Apr;7(4):1053–1059. doi: 10.1002/j.1460-2075.1988.tb02913.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  63. Stuart S. G., Trounstine M. L., Vaux D. J., Koch T., Martens C. L., Mellman I., Moore K. W. Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII). J Exp Med. 1987 Dec 1;166(6):1668–1684. doi: 10.1084/jem.166.6.1668. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Tax W. J., Hermes F. F., Willems R. W., Capel P. J., Koene R. A. Fc receptors for mouse IgG1 on human monocytes: polymorphism and role in antibody-induced T cell proliferation. J Immunol. 1984 Sep;133(3):1185–1189. [PubMed] [Google Scholar]
  65. Tax W. J., Willems H. W., Reekers P. P., Capel P. J., Koene R. A. Polymorphism in mitogenic effect of IgG1 monoclonal antibodies against T3 antigen on human T cells. Nature. 1983 Aug 4;304(5925):445–447. doi: 10.1038/304445a0. [DOI] [PubMed] [Google Scholar]
  66. Titus J. A., Perez P., Kaubisch A., Garrido M. A., Segal D. M. Human K/natural killer cells targeted with hetero-cross-linked antibodies specifically lyse tumor cells in vitro and prevent tumor growth in vivo. J Immunol. 1987 Nov 1;139(9):3153–3158. [PubMed] [Google Scholar]
  67. Tosi M. F., Berger M. Functional differences between the 40 kDa and 50 to 70 kDa IgG Fc receptors on human neutrophils revealed by elastase treatment and antireceptor antibodies. J Immunol. 1988 Sep 15;141(6):2097–2103. [PubMed] [Google Scholar]
  68. Trinchieri G., O'Brien T., Shade M., Perussia B. Phorbol esters enhance spontaneous cytotoxicity of human lymphocytes, abrogate Fc receptor expression, and inhibit antibody-dependent lymphocyte-mediated cytotoxicity. J Immunol. 1984 Oct;133(4):1869–1877. [PubMed] [Google Scholar]
  69. Unkeless J. C., Fleit H., Mellman I. S. Structural Aspects and Heterogeneity of Immunoglobulin Fc Receptors. Adv Immunol. 1981;31:247–270. doi: 10.1016/s0065-2776(08)60922-0. [DOI] [PubMed] [Google Scholar]
  70. Unkeless J. C., Scigliano E., Freedman V. H. Structure and function of human and murine receptors for IgG. Annu Rev Immunol. 1988;6:251–281. doi: 10.1146/annurev.iy.06.040188.001343. [DOI] [PubMed] [Google Scholar]
  71. Williams A. F., Barclay A. N. The immunoglobulin superfamily--domains for cell surface recognition. Annu Rev Immunol. 1988;6:381–405. doi: 10.1146/annurev.iy.06.040188.002121. [DOI] [PubMed] [Google Scholar]
  72. Willis H. E., Browder B., Feister A. J., Mohanakumar T., Ruddy S. Monoclonal antibody to human IgG Fc receptors. Cross-linking of receptors induces lysosomal enzyme release and superoxide generation by neutrophils. J Immunol. 1988 Jan 1;140(1):234–239. [PubMed] [Google Scholar]
  73. Wilson H. A., Greenblatt D., Taylor C. W., Putney J. W., Tsien R. Y., Finkelman F. D., Chused T. M. The B lymphocyte calcium response to anti-Ig is diminished by membrane immunoglobulin cross-linkage to the Fc gamma receptor. J Immunol. 1987 Mar 15;138(6):1712–1718. [PubMed] [Google Scholar]
  74. Yamasaki K., Taga T., Hirata Y., Yawata H., Kawanishi Y., Seed B., Taniguchi T., Hirano T., Kishimoto T. Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. Science. 1988 Aug 12;241(4867):825–828. doi: 10.1126/science.3136546. [DOI] [PubMed] [Google Scholar]
  75. Yancey K. B., O'Shea J., Chused T., Brown E., Takahashi T., Frank M. M., Lawley T. J. Human C5a modulates monocyte Fc and C3 receptor expression. J Immunol. 1985 Jul;135(1):465–470. [PubMed] [Google Scholar]
  76. Young J. D., Ko S. S., Cohn Z. A. The increase in intracellular free calcium associated with IgG gamma 2b/gamma 1 Fc receptor-ligand interactions: role in phagocytosis. Proc Natl Acad Sci U S A. 1984 Sep;81(17):5430–5434. doi: 10.1073/pnas.81.17.5430. [DOI] [PMC free article] [PubMed] [Google Scholar]
  77. van de Griend R. J., Tax W. J., van Krimpen B. A., Vreugdenhil R. J., Ronteltap C. P., Bolhuis R. L. Lysis of tumor cells by CD3+4-8-16+ T cell receptor alpha beta- clones, regulated via CD3 and CD16 activation sites, recombinant interleukin 2, and interferon beta 1. J Immunol. 1987 Mar 1;138(5):1627–1633. [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES