Figure 1.

Potential gene regulatory functions of LAP2α in striated muscle. Many of the observed changes in gene expression in LAP2α-deficient striated muscle tissue converge on an impaired activity of MEF2c. This impairment could contribute to the phenotypes of LAP2α-deficient mice, including impaired differentiation of myoblasts, decrease in slow, oxidative fiber types in soleus muscle and defects in heart development and stress response. For details see the text.