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. 1989 May;83(5):1443–1448. doi: 10.1172/JCI114036

Pemphigus and pemphigoid as paradigms of organ-specific, autoantibody-mediated diseases.

J R Stanley 1
PMCID: PMC303845  PMID: 2651476

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Selected References

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  1. Anhalt G. J., Bahn C. F., Labib R. S., Voorhees J. J., Sugar A., Diaz L. A. Pathogenic effects of bullous pemphigoid autoantibodies on rabbit corneal epithelium. J Clin Invest. 1981 Oct;68(4):1097–1101. doi: 10.1172/JCI110333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Anhalt G. J., Labib R. S., Voorhees J. J., Beals T. F., Diaz L. A. Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. N Engl J Med. 1982 May 20;306(20):1189–1196. doi: 10.1056/NEJM198205203062001. [DOI] [PubMed] [Google Scholar]
  3. Anhalt G. J., Patel H. P., Labib R. S., Diaz L. A., Proud D. Dexamethasone inhibits plasminogen activator activity in experimental pemphigus in vivo but does not block acantholysis. J Immunol. 1986 Jan;136(1):113–117. [PubMed] [Google Scholar]
  4. Anhalt G. J., Till G. O., Diaz L. A., Labib R. S., Patel H. P., Eaglstein N. F. Defining the role of complement in experimental pemphigus vulgaris in mice. J Immunol. 1986 Nov 1;137(9):2835–2840. [PubMed] [Google Scholar]
  5. Beutner E. H., Jordon R. E., Chorzelski T. P. The immunopathology of pemphigus and bullous pemphigoid. J Invest Dermatol. 1968 Aug;51(2):63–80. [PubMed] [Google Scholar]
  6. Bystryn J. C., Abel E., DeFeo C. Pemphigus foliaceus. Subcorneal intercellular antibodies of unique specificity. Arch Dermatol. 1974 Dec;110(6):857–861. doi: 10.1001/archderm.110.6.857. [DOI] [PubMed] [Google Scholar]
  7. Bystryn J. C., Rodriguez J. Absence of intercellular antigens in the deep layers of the epidermis in pemphigus foliaceus. J Clin Invest. 1978 Feb;61(2):339–348. doi: 10.1172/JCI108944. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Diaz L. A., Marcelo C. L. Pemphigoid and pemphigus antigens in cultured epidermal cells. Br J Dermatol. 1978 Jun;98(6):631–637. doi: 10.1111/j.1365-2133.1978.tb03581.x. [DOI] [PubMed] [Google Scholar]
  9. Diaz L. A., Weiss H. J., Calvanico N. J. Phylogenetic studies with pemphigus and pemphigoid antibodies. Acta Derm Venereol. 1978;58(6):537–540. [PubMed] [Google Scholar]
  10. Eyre R. W., Stanley J. R. Human autoantibodies against a desmosomal protein complex with a calcium-sensitive epitope are characteristic of pemphigus foliaceus patients. J Exp Med. 1987 Jun 1;165(6):1719–1724. doi: 10.1084/jem.165.6.1719. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Eyre R. W., Stanley J. R. Identification of pemphigus vulgaris antigen extracted from normal human epidermis and comparison with pemphigus foliaceus antigen. J Clin Invest. 1988 Mar;81(3):807–812. doi: 10.1172/JCI113387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Farb R. M., Dykes R., Lazarus G. S. Anti-epidermal-cell-surface pemphigus antibody detaches viable epidermal cells from culture plates by activation of proteinase. Proc Natl Acad Sci U S A. 1978 Jan;75(1):459–463. doi: 10.1073/pnas.75.1.459. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Gammon W. R., Briggaman R. A. Absence of specific histologic changes in guinea pig skin treated with bullous pemphigoid antibodies. J Invest Dermatol. 1988 Apr;90(4):495–500. doi: 10.1111/1523-1747.ep12460971. [DOI] [PubMed] [Google Scholar]
  14. Gammon W. R., Merritt C. C., Lewis D. M., Sams W. M., Jr, Carlo J. R., Wheeler C. E., Jr An in vitro model of immune complex-mediated basement membrane zone separation caused by pemphigoid antibodies, leukocytes, and complement. J Invest Dermatol. 1982 Apr;78(4):285–290. doi: 10.1111/1523-1747.ep12507222. [DOI] [PubMed] [Google Scholar]
  15. Gorbsky G., Cohen S., Steinberg M. S. Desmosomal antigens are not recognized by the majority of pemphigus autoimmune sera. J Invest Dermatol. 1983 Jun;80(6):475–480. doi: 10.1111/1523-1747.ep12534924. [DOI] [PubMed] [Google Scholar]
  16. Hashimoto K., Shafran K. M., Webber P. S., Lazarus G. S., Singer K. H. Anti-cell surface pemphigus autoantibody stimulates plasminogen activator activity of human epidermal cells. A mechanism for the loss of epidermal cohesion and blister formation. J Exp Med. 1983 Jan 1;157(1):259–272. doi: 10.1084/jem.157.1.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Hashimoto T., Sugiura M., Kurihara S., Nishikawa T. In vitro complement activation by intercellular antibodies. J Invest Dermatol. 1982 Apr;78(4):316–318. doi: 10.1111/1523-1747.ep12507396. [DOI] [PubMed] [Google Scholar]
  18. Horiguchi Y., Imamura S. Discrepancy between the localization of in vivo bound immunoglobulins in the skin and in vitro binding sites of circulating anti-BMZ antibodies in bullous pemphigoid: immunoelectron microscopic studies. J Invest Dermatol. 1986 Dec;87(6):715–719. doi: 10.1111/1523-1747.ep12456694. [DOI] [PubMed] [Google Scholar]
  19. Jones J. C., Arnn J., Staehelin L. A., Goldman R. D. Human autoantibodies against desmosomes: possible causative factors in pemphigus. Proc Natl Acad Sci U S A. 1984 May;81(9):2781–2785. doi: 10.1073/pnas.81.9.2781. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Jones J. C., Yokoo K. M., Goldman R. D. A cell surface desmosome-associated component: identification of tissue-specific cell adhesion molecule. Proc Natl Acad Sci U S A. 1986 Oct;83(19):7282–7286. doi: 10.1073/pnas.83.19.7282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Jones J. C., Yokoo K. M., Goldman R. D. Further analysis of pemphigus autoantibodies and their use in studies on the heterogeneity, structure, and function of desmosomes. J Cell Biol. 1986 Mar;102(3):1109–1117. doi: 10.1083/jcb.102.3.1109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Jordon R. E., Bushkell L. L. The complement system in pemphigus, bullous pemphigoid and herpes gestationis. Int J Dermatol. 1979 May;18(4):271–281. doi: 10.1111/j.1365-4362.1979.tb01927.x. [DOI] [PubMed] [Google Scholar]
  23. Jordon R. E., Heine K. G., Tappeiner G., Bushkell L. L., Provost T. T. The immunopathology of herpes gestationis. Immunofluorescence studies and characterization of "HG factor". J Clin Invest. 1976 Jun;57(6):1426–1431. doi: 10.1172/JCI108412. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Katz S. I., Hertz K. C., Yaoita H. Herpes gestationis. Immunopathology and characterization of the HG factor. J Clin Invest. 1976 Jun;57(6):1434–1441. doi: 10.1172/JCI108413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Kawana S., Geoghegan W. D., Jordon R. E. Complement fixation by pemphigus antibody. II. Complement enhanced detachment of epidermal cells. Clin Exp Immunol. 1985 Sep;61(3):517–525. [PMC free article] [PubMed] [Google Scholar]
  26. Kawana S., Geoghegan W. D., Jordon R. E. Complement fixation by pemphigus antibody. III. Altered epidermal cell membrane integrity mediated by pemphigus antibody and complement. J Invest Dermatol. 1986 Jan;86(1):29–33. doi: 10.1111/1523-1747.ep12283762. [DOI] [PubMed] [Google Scholar]
  27. Kawana S., Janson M., Jordon R. E. Complement fixation by pemphigus antibody. I. In vitro fixation to organ and tissue culture skin. J Invest Dermatol. 1984 May;82(5):506–510. doi: 10.1111/1523-1747.ep12261058. [DOI] [PubMed] [Google Scholar]
  28. Koulu L., Kusumi A., Steinberg M. S., Klaus-Kovtun V., Stanley J. R. Human autoantibodies against a desmosomal core protein in pemphigus foliaceus. J Exp Med. 1984 Nov 1;160(5):1509–1518. doi: 10.1084/jem.160.5.1509. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Labib R. S., Anhalt G. J., Patel H. P., Mutasim D. F., Diaz L. A. Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting. J Immunol. 1986 Feb 15;136(4):1231–1235. [PubMed] [Google Scholar]
  30. Morioka S., Lazarus G. S., Jensen P. J. Involvement of urokinase-type plasminogen activator in acantholysis induced by pemphigus IgG. J Invest Dermatol. 1987 Nov;89(5):474–477. doi: 10.1111/1523-1747.ep12460937. [DOI] [PubMed] [Google Scholar]
  31. Morrison L. H., Labib R. S., Zone J. J., Diaz L. A., Anhalt G. J. Herpes gestationis autoantibodies recognize a 180-kD human epidermal antigen. J Clin Invest. 1988 Jun;81(6):2023–2026. doi: 10.1172/JCI113554. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Mueller S., Klaus-Kovtun V., Stanley J. R. A 230-kD basic protein is the major bullous pemphigoid antigen. J Invest Dermatol. 1989 Jan;92(1):33–38. doi: 10.1111/1523-1747.ep13070476. [DOI] [PubMed] [Google Scholar]
  33. Mutasim D. F., Takahashi Y., Labib R. S., Anhalt G. J., Patel H. P., Diaz L. A. A pool of bullous pemphigoid antigen(s) is intracellular and associated with the basal cell cytoskeleton-hemidesmosome complex. J Invest Dermatol. 1985 Jan;84(1):47–53. doi: 10.1111/1523-1747.ep12274684. [DOI] [PubMed] [Google Scholar]
  34. Naito K., Morioka S., Ikeda S., Ogawa H. Experimental bullous pemphigoid in guinea pigs: the role of pemphigoid antibodies, complement, and migrating cells. J Invest Dermatol. 1984 Mar;82(3):227–230. doi: 10.1111/1523-1747.ep12260057. [DOI] [PubMed] [Google Scholar]
  35. Regnier M., Vaigot P., Michel S., Prunieras M. Localization of bullous pemphigoid antigen (BPA) in isolated human keratinocytes. J Invest Dermatol. 1985 Sep;85(3):187–190. doi: 10.1111/1523-1747.ep12276656. [DOI] [PubMed] [Google Scholar]
  36. Roscoe J. T., Diaz L., Sampaio S. A., Castro R. M., Labib R. S., Takahashi Y., Patel H., Anhalt G. J. Brazilian pemphigus foliaceus autoantibodies are pathogenic to BALB/c mice by passive transfer. J Invest Dermatol. 1985 Dec;85(6):538–541. doi: 10.1111/1523-1747.ep12277362. [DOI] [PubMed] [Google Scholar]
  37. Rubinstein N., Stanley J. R. Pemphigus foliaceus antibodies and a monoclonal antibody to desmoglein I demonstrate stratified squamous epithelial-specific epitopes of desmosomes. Am J Dermatopathol. 1987 Dec;9(6):510–514. doi: 10.1097/00000372-198712000-00007. [DOI] [PubMed] [Google Scholar]
  38. Scharf S. J., Friedmann A., Brautbar C., Szafer F., Steinman L., Horn G., Gyllensten U., Erlich H. A. HLA class II allelic variation and susceptibility to pemphigus vulgaris. Proc Natl Acad Sci U S A. 1988 May;85(10):3504–3508. doi: 10.1073/pnas.85.10.3504. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Scharf S. J., Long C. M., Erlich H. A. Sequence analysis of the HLA-DR beta and HLA-DQ beta loci from three Pemphigus vulgaris patients. Hum Immunol. 1988 May;22(1):61–69. doi: 10.1016/0198-8859(88)90052-3. [DOI] [PubMed] [Google Scholar]
  40. Schiltz J. R., Michel B., Papay R. Appearance of "pemphigus acantholysis factor" in human skin cultured with pemphigus antibody. J Invest Dermatol. 1979 Dec;73(6):575–581. doi: 10.1111/1523-1747.ep12541618. [DOI] [PubMed] [Google Scholar]
  41. Schiltz J. R., Michel B., Papay R. Pemphigus antibody interaction with human epidermal cells in culture. J Clin Invest. 1978 Oct;62(4):778–788. doi: 10.1172/JCI109189. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Schiltz J. R., Michel B. Production of epidermal acantholysis in normal human skin in vitro by the IgG fraction from pemphigus serum. J Invest Dermatol. 1976 Aug;67(2):254–260. doi: 10.1111/1523-1747.ep12513454. [DOI] [PubMed] [Google Scholar]
  43. Shimizu H., Nishikawa T. Complement fixation by Brazilian pemphigus foliaceus antibodies in vitro. Dermatologica. 1986;173(5):213–215. doi: 10.1159/000249255. [DOI] [PubMed] [Google Scholar]
  44. Sinha A. A., Brautbar C., Szafer F., Friedmann A., Tzfoni E., Todd J. A., Steinman L., McDevitt H. O. A newly characterized HLA DQ beta allele associated with pemphigus vulgaris. Science. 1988 Feb 26;239(4843):1026–1029. doi: 10.1126/science.2894075. [DOI] [PubMed] [Google Scholar]
  45. Squiquera H. L., Diaz L. A., Sampaio S. A., Rivitti E. A., Martins C. R., Cunha P. R., Lombardi C., Lavrado C., Borges P., Friedman H. Serologic abnormalities in patients with endemic pemphigus foliaceus (Fogo selvagem), their relatives, and normal donors from endemic and non-endemic areas of Brazil. J Invest Dermatol. 1988 Aug;91(2):189–191. doi: 10.1111/1523-1747.ep12464490. [DOI] [PubMed] [Google Scholar]
  46. Stanley J. R., Hawley-Nelson P., Yaar M., Martin G. R., Katz S. I. Laminin and bullous pemphigoid antigen are distinct basement membrane proteins synthesized by epidermal cells. J Invest Dermatol. 1982 Jun;78(6):456–459. doi: 10.1111/1523-1747.ep12510132. [DOI] [PubMed] [Google Scholar]
  47. Stanley J. R., Hawley-Nelson P., Yuspa S. H., Shevach E. M., Katz S. I. Characterization of bullous pemphigoid antigen: a unique basement membrane protein of stratified squamous epithelia. Cell. 1981 Jun;24(3):897–903. doi: 10.1016/0092-8674(81)90115-x. [DOI] [PubMed] [Google Scholar]
  48. Stanley J. R., Klaus-Kovtun V., Sampaio S. A. Antigenic specificity of fogo selvagem autoantibodies is similar to North American pemphigus foliaceus and distinct from pemphigus vulgaris autoantibodies. J Invest Dermatol. 1986 Aug;87(2):197–201. doi: 10.1111/1523-1747.ep12695334. [DOI] [PubMed] [Google Scholar]
  49. Stanley J. R., Koulu L., Thivolet C. Distinction between epidermal antigens binding pemphigus vulgaris and pemphigus foliaceus autoantibodies. J Clin Invest. 1984 Aug;74(2):313–320. doi: 10.1172/JCI111426. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Stanley J. R., Tanaka T., Mueller S., Klaus-Kovtun V., Roop D. Isolation of complementary DNA for bullous pemphigoid antigen by use of patients' autoantibodies. J Clin Invest. 1988 Dec;82(6):1864–1870. doi: 10.1172/JCI113803. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Stanley J. R., Woodley D. T., Katz S. I. Identification and partial characterization of pemphigoid antigen extracted from normal human skin. J Invest Dermatol. 1984 Jan;82(1):108–111. doi: 10.1111/1523-1747.ep12259224. [DOI] [PubMed] [Google Scholar]
  52. Stanley J. R., Yuspa S. H. Specific epidermal protein markers are modulated during calcium-induced terminal differentiation. J Cell Biol. 1983 Jun;96(6):1809–1814. doi: 10.1083/jcb.96.6.1809. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Szafer F., Brautbar C., Tzfoni E., Frankel G., Sherman L., Cohen I., Hacham-Zadeh S., Aberer W., Tappeiner G., Holubar K. Detection of disease-specific restriction fragment length polymorphisms in pemphigus vulgaris linked to the DQw1 and DQw3 alleles of the HLA-D region. Proc Natl Acad Sci U S A. 1987 Sep;84(18):6542–6545. doi: 10.1073/pnas.84.18.6542. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Westgate G. E., Weaver A. C., Couchman J. R. Bullous pemphigoid antigen localization suggests an intracellular association with hemidesmosomes. J Invest Dermatol. 1985 Mar;84(3):218–224. doi: 10.1111/1523-1747.ep12265229. [DOI] [PubMed] [Google Scholar]
  55. Wood G. W., Beutner E. H. Blocking-immunofluorescence studies on the specificity of pemphigus autoantibodies. Clin Immunol Immunopathol. 1977 Mar;7(2):168–175. doi: 10.1016/0090-1229(77)90045-9. [DOI] [PubMed] [Google Scholar]
  56. Zhu X. J., Bystryn J. C. Heterogeneity of pemphigoid antigens. J Invest Dermatol. 1983 Jan;80(1):16–20. doi: 10.1111/1523-1747.ep12530900. [DOI] [PubMed] [Google Scholar]

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