Table 4.
Genotype-phenotype association between ADRB2 (beta-2 adrenergic receptor) polymorphisms and gamma-glutamyl transpeptidase in twins.
| SNP domain | Diploid genotype code |
Gamma-glutamyl transpeptidase, IU/L |
Diploid genotype bases |
N | P value | |
|---|---|---|---|---|---|---|
| Mean | SEM | |||||
| Promoter G-1023A | 1 | 18.2 | 1.4 | G/G | 109 | 0.025 |
| (rs2053044) | 2 | 23.3 | 1.7 | G/A | 136 | |
| 3 | 24.9 | 3.3 | A/A | 80 | ||
| Promoter C-468G | 1 | 19.4 | 1.1 | C/C | 106 | 0.015 |
| (rs11168070) | 2, 3 | 24.7 | 1.9 | C/G or G/G | 221 | |
| Promoter T-367C | 1 | 19.6 | 1.1 | T/T | 112 | 0.021 |
| (rs11959427) | 2, 3 | 24.7 | 2.0 | T/C or C/C | 219 | |
| Promoter T-47C | 1 | 19.5 | 1.1 | T/T | 117 | 0.012 |
| (rs1042711) | 2, 3 | 24.8 | 1.9 | T/C or C/C | 213 | |
| Glu27Gln, G298C | 1 | 19.5 | 1.1 | C/C | 104 | 0.016 |
| (rs1042714) | 2, 3 | 24.8 | 1.9 | C/G or G/G | 224 | |
Footnote:
This table shows that five SNPs in the beta-2-adrenergic receptor gene (ADRB2) predict with plasma GGT, a marker of fatty liver. SNP statistics for twin study population are derived from generalized estimating equations (GEEs; PROC GENMOD) in SAS, version 9.1 (SAS Institute, Cary, NC) to account for correlations within twinships. Results are displayed for trait (plasma GGT) mean (IU/L, ± one SEM). All analyses are adjusted for age and sex. GGT was treated as a continuous outcome variable. A two-tailed p-value of ≤0.05 was considered statistically significant.