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. 1989 Jun;83(6):2125–2130. doi: 10.1172/JCI114126

Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits.

R W Mahley 1, K H Weisgraber 1, M M Hussain 1, B Greenman 1, M Fisher 1, T Vogel 1, M Gorecki 1
PMCID: PMC303940  PMID: 2723074

Abstract

Plasma cholesterol levels in cholesterol-fed rabbits were markedly reduced by the intravenous infusion or bolus injection of recombinant human apo E or rabbit plasma apo E. Administration of 6-70 mg of apo E resulted in an approximately 20-40% acute reduction in plasma cholesterol levels within 2-3 h. Plasma cholesterol levels remained reduced for 4-8 h after the administration of apo E. Furthermore, the intravenous injection of apo E reduced the plasma cholesterol levels in Watanabe heritable hyperlipidemic rabbits. The addition of apo E to [14C]cholesterol-labeled canine thoracic duct lymph or [14C]cholesterol-labeled chylomicrons resulted in accelerated plasma clearance of these diet-induced lipoproteins in normal rabbits, with the uptake occurring primarily in the liver. This study suggests that the amount or availability of apo E in the plasma of cholesterol-fed rabbits may be rate limiting for the normal clearance of diet-induced remnant lipoproteins.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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