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. 1989 Dec;84(6):1900–1905. doi: 10.1172/JCI114377

Quantitative contribution of systemic vascular autoregulation in acute hypertension in conscious dogs.

P J Metting 1, K A Kostrzewski 1, P M Stein 1, B A Stoos 1, S L Britton 1
PMCID: PMC304070  PMID: 2592565

Abstract

Experiments were performed in nine conscious dogs to quantitate the contribution of systemic vascular autoregulation to the increases in total peripheral resistance (TPR) and mean arterial pressure (MAP) produced by angiotensin II (ANG II), arginine vasopressin (AVP), and norepinephrine (NE). We hypothesized that if autoregulatory vasoconstriction is significant, then the increase in TPR produced by vasoconstrictor infusion will be greater when MAP is controlled at hypertensive values than when the increase in pressure is prevented by controlling MAP at the animal's normotensive value. Each drug was infused at a dose sufficient to increase MAP by 50%. Then, a constant rate of vasoconstrictor infusion was maintained while MAP was controlled at hypertensive or normotensive levels for 15-min periods using a gravity reservoir connected to the left common carotid artery. During AVP infusion, TPR was significantly greater when MAP was controlled at hypertensive than at normotensive values. This autoregulatory-mediated vasoconstriction accounted for approximately three-fourths of the increase in MAP produced by AVP. No significant autoregulatory component was identified for the increases in TPR and MAP produced by ANG II or NE. We conclude that systemic vascular autoregulation is a powerful physiological property that contributes to the hemodynamic response to pressor doses of AVP.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BORST J. G., BORST-DE GEUS A. Hypertension explained by Starling's theory of circulatory homoeostasis. Lancet. 1963 Mar 30;1(7283):677–682. doi: 10.1016/s0140-6736(63)91443-0. [DOI] [PubMed] [Google Scholar]
  2. Britton S. L., Metting P. J., Ronau T. F., Strader J. R., Weldy D. L. Autoregulation of hind-limb blood flow in conscious dogs. J Physiol. 1985 Nov;368:409–422. doi: 10.1113/jphysiol.1985.sp015865. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Coleman T. G., Samar R. E., Murphy W. R. Autoregulation versus other vasoconstrictors in hypertension. A critical review. Hypertension. 1979 May-Jun;1(3):324–330. doi: 10.1161/01.hyp.1.3.324. [DOI] [PubMed] [Google Scholar]
  4. Cowley A. W., Jr, Barber B. J. Vasopressin vascular and reflex effects--a theoretical analysis. Prog Brain Res. 1983;60:415–424. doi: 10.1016/S0079-6123(08)64408-8. [DOI] [PubMed] [Google Scholar]
  5. Cowley A. W., Jr, Monos E., Guyton A. C. Interaction of vasopressin and the baroreceptor reflex system in the regulation of arterial blood pressure in the dog. Circ Res. 1974 Apr;34(4):505–514. doi: 10.1161/01.res.34.4.505. [DOI] [PubMed] [Google Scholar]
  6. Cowley A. W., Jr The concept of autoregulation of total blood flow and its role in hypertension. Am J Med. 1980 Jun;68(6):906–916. doi: 10.1016/0002-9343(80)90225-9. [DOI] [PubMed] [Google Scholar]
  7. Crofton J. T., Share L., Shade R. E., Lee-Kwon W. J., Manning M., Sawyer W. H. The importance of vasopressin in the development and maintenance of DOC-salt hypertension in the rat. Hypertension. 1979 Jan-Feb;1(1):31–38. doi: 10.1161/01.hyp.1.1.31. [DOI] [PubMed] [Google Scholar]
  8. Gavras H., Brunner H. R., Laragh J. H., Vaughan E. D., Jr, Koss M., Cote L. J., Gavras I. Malignant hypertension resulting from deoxycorticosterone acetate and salt excess: role of renin and sodium in vascular changes. Circ Res. 1975 Feb;36(2):300–309. doi: 10.1161/01.res.36.2.300. [DOI] [PubMed] [Google Scholar]
  9. Granger H. J., Goodman A. H., Granger D. N. Role of resistance and exchange vessels in local microvascular control of skeletal muscle oxygenation in the dog. Circ Res. 1976 May;38(5):379–385. doi: 10.1161/01.res.38.5.379. [DOI] [PubMed] [Google Scholar]
  10. Granger H. J., Guyton A. C. Autoregulation of the total systemic circulation following destruction of the central nervous system in the dog. Circ Res. 1969 Oct;25(4):379–388. doi: 10.1161/01.res.25.4.379. [DOI] [PubMed] [Google Scholar]
  11. Guyton A. C. The relationship of cardiac output and arterial pressure control. Circulation. 1981 Dec;64(6):1079–1088. doi: 10.1161/01.cir.64.6.1079. [DOI] [PubMed] [Google Scholar]
  12. Heyndrickx G. R., Boettcher D. H., Vatner S. F. Effects of angiotensin, vasopressin, and methoxamine on cardiac function and blood flow distribution in conscious dogs. Am J Physiol. 1976 Nov;231(5 Pt 1):1579–1587. doi: 10.1152/ajplegacy.1976.231.5.1579. [DOI] [PubMed] [Google Scholar]
  13. Hinojosa-Laborde C., Greene A. S., Cowley A. W., Jr Autoregulation of the systemic circulation in conscious rats. Hypertension. 1988 Jun;11(6 Pt 2):685–691. doi: 10.1161/01.hyp.11.6.685. [DOI] [PubMed] [Google Scholar]
  14. Liard J. F., Dériaz O., Schelling P., Thibonnier M. Cardiac output distribution during vasopressin infusion or dehydration in conscious dogs. Am J Physiol. 1982 Nov;243(5):H663–H669. doi: 10.1152/ajpheart.1982.243.5.H663. [DOI] [PubMed] [Google Scholar]
  15. Meininger G. A., Lubrano V. M., Granger H. J. Hemodynamic and microvascular responses in the hindquarters during the development of renal hypertension in rats. Evidence for the involvement of an autoregulatory component. Circ Res. 1984 Nov;55(5):609–622. doi: 10.1161/01.res.55.5.609. [DOI] [PubMed] [Google Scholar]
  16. Meininger G. A., Routh L. K., Granger H. J. Autoregulation and vasoconstriction in the intestine during acute renal hypertension. Hypertension. 1985 May-Jun;7(3 Pt 1):364–373. [PubMed] [Google Scholar]
  17. Meininger G. A., Trzeciakowski J. P. Vasoconstriction is amplified by autoregulation during vasoconstrictor-induced hypertension. Am J Physiol. 1988 Apr;254(4 Pt 2):H709–H718. doi: 10.1152/ajpheart.1988.254.4.H709. [DOI] [PubMed] [Google Scholar]
  18. Metting P. J., Strader J. R., Britton S. L. Evaluation of whole body autoregulation in conscious dogs. Am J Physiol. 1988 Jul;255(1 Pt 2):H44–H52. doi: 10.1152/ajpheart.1988.255.1.H44. [DOI] [PubMed] [Google Scholar]
  19. Möhring J., Möhring B., Petri M., Haack D. Plasma vasopressin concentrations and effects of vasopressin antiserum on blood pressure in rats with malignant two-kidney Goldblatt hypertension. Circ Res. 1978 Jan;42(1):17–22. doi: 10.1161/01.res.42.1.17. [DOI] [PubMed] [Google Scholar]
  20. Möhring J., Möhring B., Petri M., Haack D. Vasopressor role of ADH in the pathogenesis of malignant DOC hypertension. Am J Physiol. 1977 Mar;232(3):F260–F269. doi: 10.1152/ajprenal.1977.232.3.F260. [DOI] [PubMed] [Google Scholar]
  21. Noble M. I., Gabe I. T., Trenchard D., Guz A. Blood pressure and flow in the ascending aorta of conscious dogs. Cardiovasc Res. 1967 Jan;1(1):9–20. doi: 10.1093/cvr/1.1.9. [DOI] [PubMed] [Google Scholar]
  22. Sagawa K., Eisner A. Static pressure-flow relation in the total systemic vascular bed of the dog and its modification by the baroreceptor reflex. Circ Res. 1975 Mar;36(3):406–413. doi: 10.1161/01.res.36.3.406. [DOI] [PubMed] [Google Scholar]
  23. Shepherd A. P., Granger H. J., Smith E. E., Guyton A. C. Local control of tissue oxygen delivery and its contribution to the regulation of cardiac output. Am J Physiol. 1973 Sep;225(3):747–755. doi: 10.1152/ajplegacy.1973.225.3.747. [DOI] [PubMed] [Google Scholar]
  24. Shoukas A. A., Brunner M. J., Frankle A. E., Greene A. S., Kallman C. H. Carotid sinus baroreceptor reflex control and the role of autoregulation in the systemic and pulmonary arterial pressure-flow relationships of the dog. Circ Res. 1984 Jun;54(6):674–682. doi: 10.1161/01.res.54.6.674. [DOI] [PubMed] [Google Scholar]
  25. WHIMSTER W. F. Idiopathic intussusception in the adult. Lancet. 1963 Apr 20;1(7286):887–887. doi: 10.1016/s0140-6736(63)91659-3. [DOI] [PubMed] [Google Scholar]

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