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. 1987 Jan;84(1):228–231. doi: 10.1073/pnas.84.1.228

Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production.

T Hirano, T Taga, K Yasukawa, K Nakajima, N Nakano, F Takatsuki, M Shimizu, A Murashima, S Tsunasawa, F Sakiyama, et al.
PMCID: PMC304176  PMID: 3491991

Abstract

The partial amino acid sequence of the NH2 terminus of a factor named human B-cell differentiation factor or B-cell stimulatory factor 2 (BSF-2) has been determined. Antibodies raised against the synthetic peptide corresponding to residues 1-13 of the NH2-terminal sequence specifically react with BSF-2 generated by a T-cell line and by phytohemagglutinin-stimulated normal T cells. Furthermore, the antipeptide antibodies react with a BSF-2-like factor produced by cardiac myxoma as well as uterine cervical carcinoma cells. The results show that BSF-2 functions in vivo as well and suggest that the constitutive production of BSF-2 may be involved in autoantibody production, since patients with cardiac myxoma and uterine carcinoma showed autoantibody production.

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Selected References

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