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. 1987 Feb;84(3):842–846. doi: 10.1073/pnas.84.3.842

Basic fibroblast growth factor in human rhabdomyosarcoma cells: implications for the proliferation and neovascularization of myoblast-derived tumors.

L Schweigerer, G Neufeld, A Mergia, J A Abraham, J C Fiddes, D Gospodarowicz
PMCID: PMC304312  PMID: 2433691

Abstract

Cultured human embryonal rhabdomyosarcoma cells express the basic fibroblast growth factor (bFGF) gene and they produce bFGF, which is apparently composed of two microheterogenous forms with Mrs of 16,500 and 17,200, respectively. bFGF derived from the rhabdomyosarcoma cells stimulates their own proliferation and that of human or bovine vascular endothelial cells. It is conceivable that the rhabdomyosarcoma-derived bFGF stimulates the growth and neovascularization of human rhabdomyosarcomas and that it may thereby contribute to the development of these tumors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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