Fig. 3.

HLA-A*03–associated viral polymorphisms at (A) positions 1087 and 1088 in NS3 and (B) position 2518 in NS5B. Sequences in regions of interest (from Table 1) are displayed for HLA-A*03⁺ and HLA-A*03⁻ subjects. The sequence identity with the source sequence is identified by a dot. Amino acid mixtures at a site are separated by a forward slash. The number of individuals with a particular sequence is shown in the count column. The lysine (K) to arginine (R) substitution at 2518 (8 of 15 HLA-A*03⁺ subjects versus 4 of 47 HLA-A*03⁻ subjects) resulted in a change in the SYFPEITHI-predicted binding score from 27 to 21. Only one HLA-A*03 individual with chronic infection did not have a polymorphism at the 1087 or 1088 site in NS3 or at the 2518 site in NS5B.