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. Author manuscript; available in PMC: 2011 Feb 24.
Published in final edited form as: Oncogene. 2010 Nov 8;30(6):751–756. doi: 10.1038/onc.2010.480

Figure 2. γIR does not lead to the persistent induction of genomic instability in primary bystanders to Dnmt1-/- Dnmt3a-/- Dnmt3b-/- cells.

Figure 2

DNA damage by comet assay (a) and SCEs (b) in naive WT ES cells exposed to media from WT and Dnmt1-/- Dnmt3a-/- Dnmt3b-/- cells. See Fig. 1 for experimental design. SCEs were counted for ≥80 spreads/condition as previously described (Engelward et al., 1996). For SCE studies, median with interquartile range is shown and P values were produced by a two-tailed t-test.