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. 1987 Mar;84(5):1459–1463. doi: 10.1073/pnas.84.5.1459

Synthesis of sodium channels in the cell bodies of squid giant axons.

T Brismar, W F Gilly
PMCID: PMC304450  PMID: 3469679

Abstract

Giant axons in squid are formed by fusion of axons from many small cell bodies in the giant fiber lobe (GFL) of the stellate ganglion. Somata of GFL cells in vivo are inexcitable and do not have measurable sodium current (INa) when studied with microelectrode or patch-electrode voltage-clamp techniques. If GFL cells are separated from the giant axons and maintained in primary culture, axon-like INa can be recorded from the somata after several days. Incorporation of Na channels into GFL cell bodies requires protein synthesis, intracellular microtubule-based transport, and the lack of a morphologically defined axon to serve as a sink for channels synthesized in culture.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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