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. 2011 Mar;132(3):361–375. doi: 10.1111/j.1365-2567.2010.03369.x

Figure 4.

Figure 4

Thy-1 cross-linking augments α-galactosylceramide (αGC)-mediated cytokine secretion by mouse CD4+ invariant natural killer (iNKT) cells. N38-2C12 cells were co-incubated with bone marrow-derived dendritic cells and stimulated with αGC alone (100 ng/ml), with a low (5 μg/ml) or high (40 μg/ml) dose of G7, or with a combination of αGC and G7. After 24 hr, culture supernatants were harvested and interleukin-2 (IL-2), interferon-γ (IFN-γ) and IL-4 levels were measured by ELISA. ** and *** represent P < 0·01 and P < 0·001, respectively. Adding G7 to bone marrow-derived dendritic cells alone did not result in cytokine secretion (not shown).