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. Author manuscript; available in PMC: 2011 Feb 25.
Published in final edited form as: Alcohol Clin Exp Res. 2008 May;32(5):895–908. doi: 10.1111/j.1530-0277.2008.00659.x

Table 2. Summary of Ethanol Sensitivity and Tolerance Mutants.

Ethanol phenotype
Mutant name (line) Other ethanol phenotypes Gene(s) implicated based on P-element position
Increased sensitivity
 barbos-1 (C0015) – 1,782 bp 5′ of CG6044 (novel) ⪡ 371 bp 5′ of CG3624 (Ig repeat)
 box (E1847) – ⪡Gclm (glutathione biosynthesis)
 ikar (C0108) LRT 4,158 bp 3′ of CG6930 (zinc finger TF)⪡37 bp 5′ of Lk6 (kinase)
 iks (A0544) LCT ≫rhomboid (EGFR-activating peptidase)
 joy (E3947) – ≫cheerio (actin-binding)
 milord-1 (E0469) LRT ≫pumilio (translational regulator)
 milord-2 (E2655) – ⪡pumilio (translational regulator)
 premjera (E3945) – ≫CG1910 (novel)
 rafael (D0264) LCT 1,151 bp 3′ of CG5208 ⪡ 6,075 bp 5′ of Dad (negative regulator of TGF-β)
 ruslan (D0417) LRT, LCT ⪡klingon (Ig superfamily; neurogenesis)
 zolotistuy (E0511) LRT ⪡formin3 (actin assembly promoting)
Decreased sensitivity
 krasavietz (C0150) LRT, LCT ⪡exba (eIF-5C) (translational regulation; axon guidance)
 murashka-2 (E3803) – ⪡CG9381 (RING finger)
Reduced rapid tolerance
 ikar (C0108) S 4,158 bp 3′ of CG6930 (zinc finger TF) ⪡ 37 bp 5′ of Lk6 (kinase)
 krasavietz (C0150) R, LCT ⪡exba (eIF-5C) (translational regulation; axon guidance)
 milord-1 (E0469) S ≫pumilio (translational regulator)
 rogdi (C0113) – ⪡CG7725 (novel)
 ruslan (D0417) S, LCT ⪡klingon (Ig superfamily; neurogenesis)
 valiet-1 (A0023) – ⪡RluA-1 (pseudouridine synthase; RNA metabolism)
 valiet-3 (C0085) – ⪡RluA-1: same as valiet-1
 zolotistuy (E0511) S ⪡formin3 (actin assembly promoting)
Reduced chronic tolerance
 baikal (E1715) – ⪡paxillinB (Hh/smo signaling; neurogenesis)
 diana (E0391) – 250 bp 5′ of CG14696 (novel) ≫ 463 bp 5′ of CG4674 (novel)
 iks (A0544) S ≫rhomboid (EGFR-activating peptidase)
 jack (E3548) – 30 bp 5′ of CG2765 (novel) ⪡ 443 bp 3′ of CG30424 (novel)
 krasavietz (C0150) R, LRT ⪡exba (eIF-5C) (translational regulation; axon guidance)
 rafael (D0264) S 1,151 bp 3′ of CG5208 ⪡ 6,075 bp 5′ of Dad (negative regulator of TGF-β)
 ruslan (D0417) S, LRT ⪡klingon (Ig superfamily; neurogenesis)
 visgun (E4203) – ⪡CG16707 (endolyn homolog)
Enhanced chronic tolerance
 john (E4526) – 37 bp 5′ of CG5384 (ubiquitin-specific protease) ≫ 107 bp 5′ of CG4972 (Zn-dependent exopeptidase)

See Table 1 and text for details. Ethanol phenotypes are abbreviated as in Table 1. No mutants showed enhanced rapid tolerance.