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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Biomaterials. 2011 Feb 5;32(12):3151–3157. doi: 10.1016/j.biomaterials.2011.01.024

Table 1. Material properties of enamel from wild type and M180 knock in animals; means and standard deviations.

Dentine and enamel hardness and enamel toughness were determined for incisors from M180 knock in and wild type animals. Statistically significant reduction (p<0.002) in toughness of the M180 knock in enamel was identified, suggesting that while it functioned normally in the animal for mastication, it was none the less 22% less tough than the wild type counterpart. Conversely, a statistically significant (p<0.001) increase in hardness of the M180 knock in animal was identified.

ANIMAL
TYPE		 ENAMEL
HARDNESS
GPa		 ENAMEL
TOUGHNESS
MPa·m1/2 		DENTIN
HARDNESS
GPa
M180 KI 2.6 (0.1) 1.0 (0.1) 0.66 (0.09)
Wild Type 2.3 (0.1) 1.3 (0.1) 0.66 (0.07)
Change + 7 % − 22 % none
P 0.001 0.002 0.4