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. 1987 Apr;84(7):2015–2018. doi: 10.1073/pnas.84.7.2015

Mapping the X-linked lymphoproliferative syndrome.

J C Skare, A Milunsky, K S Byron, J L Sullivan
PMCID: PMC304574  PMID: 2882515

Abstract

The X-linked lymphoproliferative syndrome is triggered by Epstein-Barr virus infection and results in fatal mononucleosis, immunodeficiency, and lymphoproliferative disorders. This study shows that the mutation responsible for X-linked lymphoproliferative syndrome is genetically linked to a restriction fragment length polymorphism detected with the DXS42 probe (from Xq24-q27). The most likely recombination frequency between the loci is 4%, and the associated logarithm of the odds is 5.26. Haplotype analysis using flanking restriction fragment length polymorphism markers indicates that the locus for X-linked lymphoproliferative syndrome is distal to probe DXS42 but proximal to probe DXS99 (from Xq26-q27). It is now possible to predict which members of a family with X-linked lymphoproliferative syndrome are carrier females and to diagnose the syndrome prenatally.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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