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. 1987 Apr;84(8):2251–2255. doi: 10.1073/pnas.84.8.2251

Activation of pp60c-src protein kinase activity in human colon carcinoma.

J B Bolen, A Veillette, A M Schwartz, V DeSeau, N Rosen
PMCID: PMC304627  PMID: 2436227

Abstract

The tyrosine-specific protein kinase activity of pp60c-src molecules obtained from human colon carcinoma tissues and tumor-derived cell lines was found to be elevated over that from normal colon tissues or cultures of normal colon mucosal cells. The elevated pp60c-src protein kinase activity in tumor tissues and in cultured colon carcinoma cells does not appear to result solely from an increase in the abundance of the c-src-encoded protein, suggesting that the specific activity of the pp60c-src tyrosine phosphotransferase is enhanced. These results raise the possibility that activation of the pp60c-src protein kinase may contribute to the genesis of human colon tumors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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