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. 1987 Apr;84(8):2508–2512. doi: 10.1073/pnas.84.8.2508

Chemical and serological investigations on the genus-specific lipopolysaccharide epitope of Chlamydia.

H Brade, L Brade, F E Nano
PMCID: PMC304683  PMID: 2436232

Abstract

Members of the bacterial genus Chlamydia are responsible for widespread disease among humans and animals, including endemic trachoma in developing countries, venereal disease in developed countries, and a variety of other diseases such as infantile pneumonia and lymphogranuloma venereum. Although there is little genetic relatedness between and large antigenic diversity between and among the two chlamydial species, one antigenic determinant has been preserved among all serovars: the genus-specific lipopolysaccharide epitope. In this report, the tools of molecular genetics, monoclonal antibodies, and analytical and synthetic chemistry have been combined to determine the structure of this epitope. This epitope is attributed to the presence of a trisaccharide of 3-deoxy-D-manno-octulosonic acid (KDO) of the sequence KDOp-(2----8)-KDOp-(2----4)-KDO. The structure includes a unique linkage of two KDO residues through a 2.8-linkage.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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