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. 2011 Feb 21;60(3):960–968. doi: 10.2337/db10-1361

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 2. — PAM staining of kidney sections and the expression of type IV collagen in the kidney. A: Representative glomeruli from control, DM, and DM+GW0742 mice. Glomerular hypertrophy and mesangial matrix expansion were evident in the DM group. GW0742 suppressed the increase in the MMI compared with the DM group. Original magnification ×400. B: MMI in glomeruli. Data are means ± SE. *P < 0.001. C: Type IV collagen was significantly increased in the DM group compared with the control group and was decreased in the DM+GW0742 group compared with the DM group. Original magnification ×400. D: Type IV collagen–positive area in glomeruli. Data are means ± SE. *P < 0.001. (A high-quality digital representation of this figure is available in the online issue.)