Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Feb 21;60(3):960–968. doi: 10.2337/db10-1361

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

PMC Copyright notice

FIG. 7. — Schematic diagram showing the mechanisms involved in the renoprotective effects of PPARδ in diabetic nephropathy. The anti-inflammatory transcriptional repressor Bcl-6 represses the expression of MCP-1. PPARδ activation by GW0742 releases Bcl-6, which is associated with suppression of MCP-1, to attenuate macrophage infiltration, inflammatory gene expression, and type IV collagen accumulation in the kidney.