Table III.
HRG | MAPK1 | RUNX2 | RUNX1 | CIMP+ | ||||
rs11913721 (A > C) | rs12333172 (C > T) | rs2071029 (G > A) | Controls | Cases | OR | (95% CI) | ||
CC | TT | GA/AA | Na | Nb | ||||
1 | * | 295 | 55 | 1.44 | (1.04, 1.99) | |||
1 | * | 65 | 20 | 2.32 | (1.37, 3.92) | |||
1 | * | 559 | 94 | 1.32 | (1.00, 1.73) | |||
2 | * | * | 13 | 1 | 0.55 | (0.07, 4.28) | ||
2 | * | * | 83 | 20 | 1.93 | (1.14, 3.26) | ||
2 | * | * | 17 | 5 | 2.51 | (0.90, 7.00) | ||
3 | * | * | * | 2 | 0 | undefined | ||
RUNX2 | RUNX3 | EIF4EBP2 | RUNX1 | KRAS2 | ||||
rs10948238 (C > T) | rs6672420 (A > T) | rs7078987 (A > G) | rs8134380 (A > T) | Controls | Cases | OR | (95% CI) | |
TT | AA/AT | GG | AA | N | Nc | |||
1 | * | 316 | 81 | 1.55 | (1.18, 2.05) | |||
1 | * | 1504 | 284 | 1.35 | (1.01, 1.81) | |||
1 | * | 413 | 88 | 1.36 | (1.04, 1.78) | |||
1 | * | 605 | 144 | 1.53 | (1.21, 1.94) | |||
2 | * | * | 255 | 62 | 2.09 | (1.37, 3.18) | ||
2 | * | * | 69 | 18 | 1.85 | (1.07, 3.19) | ||
2 | * | * | 94 | 34 | 2.51 | (1.61, 3.91) | ||
2 | * | * | 321 | 71 | 1.81 | (1.21, 2.73) | ||
2 | * | * | 469 | 113 | 2.26 | (1.49, 3.43) | ||
2 | * | * | 123 | 39 | 2.24 | (1.50, 3.35) | ||
3 | * | * | * | 58 | 13 | 2.21 | (1.08, 4.50) | |
3 | * | * | * | 77 | 28 | 4.59 | (2.39, 8.82) | |
3 | * | * | * | 18 | 10 | 4.54 | (2.01, 10.25) | |
3 | * | * | * | 96 | 30 | 3.48 | (1.90, 6.36) | |
4 | * | * | * | * | 16 | 8 | 8.66 | (2.99, 25.09) |
RUNX2 | RUNX1 | EIF4EBP3 | RUNX3 | TP53 | ||||
rs12333172 (C > T) | rs2248720 (A > C) | rs250425 (C > T) | rs6672420 (A > T) | Controls | Cases | OR | (95% CI) | |
TT | AA | CC | AA | N | Nd | |||
1 | * | 65 | 29 | 1.76 | (1.12, 2.76) | |||
1 | * | 503 | 162 | 1.29 | (1.04, 1.60) | |||
1 | * | 1120 | 328 | 1.30 | (1.06, 1.60) | |||
1 | * | 495 | 167 | 1.44 | (1.17, 1.79) | |||
2 | * | * | 11 | 7 | 2.65 | (1.01, 6.92) | ||
2 | * | * | 31 | 18 | 2.72 | (1.48, 5.00) | ||
2 | * | * | 17 | 14 | 3.56 | (1.73, 7.33) | ||
2 | * | * | 273 | 102 | 1.71 | (1.26, 2.33) | ||
2 | * | * | 136 | 52 | 1.74 | (1.22, 2.48) | ||
2 | * | * | 282 | 108 | 1.88 | (1.40, 2.53) | ||
3 | * | * | * | 3 | 6 | 11.35 | (2.69, 47.88) | |
3 | * | * | * | 4 | 4 | 4.55 | (1.12, 18.55) | |
3 | * | * | * | 8 | 9 | 5.89 | (2.19, 15.81) | |
3 | * | * | * | 79 | 30 | 1.78 | (1.09, 2.92) | |
4 | * | * | * | * | 1 | 3 | 17.80 | (1.73, 183.42) |
RUNX1 | EIF4EBP2 | RUNX3 | MAPK1 | MSI+ | ||||
rs2242878 (C > T) | rs7078987 (A > G) | rs906296 (C > G) | rs9610375 (G > T) | Controls | Cases | OR | (95% CI) | |
CT/TT | AA/AG | GG | GG | N | Ne | |||
1 | * | 638 | 80 | 1.60 | (1.17, 2.17) | |||
1 | * | 1514 | 156 | 1.51 | (1.00, 2.30) | |||
1 | * | 115 | 17 | 1.58 | (0.92, 2.69) | |||
1 | * | 559 | 72 | 1.60 | (1.17, 2.18) | |||
2 | * | * | 485 | 64 | 2.66 | (1.44, 4.94) | ||
2 | * | * | 35 | 8 | 2.82 | (1.26, 6.31) | ||
2 | * | * | 194 | 36 | 2.68 | (1.73, 4.14) | ||
2 | * | * | 90 | 14 | 2.27 | (1.13, 4.57) | ||
2 | * | * | 429 | 57 | 2.91 | (1.56, 5.45) | ||
2 | * | * | 29 | 4 | 1.77 | (0.61, 5.15) | ||
3 | * | * | * | 25 | 7 | 7.07 | (2.38, 21.01) | |
3 | * | * | * | 145 | 27 | 5.16 | (2.16, 12.35) | |
3 | * | * | * | 9 | 1 | 1.39 | (0.17, 11.29) | |
3 | * | * | * | 23 | 3 | 3.49 | (0.88, 13.83) | |
4 | * | * | * | * | 5 | 1 | 6.88 | (0.63, 75.06) |
RUNX2 | EIF4E | RUNX1 | CIMP+ and KRAS2 | |||||
rs10948238 (C > T) | rs11727086 (A > G) | rs1474479 (G > A) | Controls | Cases | OR | (95% CI) | ||
TT | AG/GG | GG/GA | N | Nf | ||||
1 | * | 316 | 19 | 1.79 | (1.04, 3.07) | |||
1 | * | 839 | 40 | 1.68 | (1.04, 2.71) | |||
1 | * | 1705 | 70 | 2.53 | (0.91, 7.00) | |||
2 | * | * | 125 | 13 | 3.63 | (1.81, 7.30) | ||
2 | * | * | 268 | 19 | 3.27 | (1.08, 9.90) | ||
2 | * | * | 721 | 38 | 3.38 | (0.80, 14.31) | ||
3 | * | * | * | 103 | 13 | 7.47 | (1.58, 35.32) | |
RUNX2 | RUNX1 | MAPK1 | RUNX3 | CIMP+ and MSI+ | ||||
rs1321075 (C > A) | rs2242878 (C > T) | rs8136867 (A > G) | rs906296 (C > G) | Controls | Cases | OR | (95% CI) | |
CC | CT/TT | GG | GG | N | Ng | |||
1 | * | 1437 | 90 | 1.75 | (1.04, 2.94) | |||
1 | * | 638 | 52 | 1.94 | (1.31, 2.87) | |||
1 | * | 411 | 39 | 2.20 | (1.46, 3.33) | |||
1 | * | 115 | 13 | 2.03 | (1.10, 3.76) | |||
2 | * | * | 463 | 44 | 3.30 | (1.61, 6.77) | ||
2 | * | * | 320 | 30 | 5.75 | (2.55, 12.94) | ||
2 | * | * | 86 | 12 | 3.75 | (1.72, 8.21) | ||
2 | * | * | 146 | 19 | 4.21 | (2.30, 7.68) | ||
2 | * | * | 35 | 6 | 4.07 | (1.61, 10.33) | ||
2 | * | * | 20 | 3 | 3.91 | (1.09, 14.00) | ||
3 | * | * | * | 105 | 14 | 9.75 | (3.14, 30.31) | |
3 | * | * | * | 22 | 6 | 11.00 | (3.37, 35.96) | |
3 | * | * | * | 14 | 2 | 10.30 | (1.78, 59.71) | |
3 | * | * | * | 7 | 1 | 4.36 | (0.50, 38.03) | |
4 | * | * | * | * | 3 | 1 | 76.32 | (3.10, 1879.34) |
HRG, high-risk genotypes. Rows are not mutually exclusive and include all individuals with the starred high-risk genotype versus those without any of the starred high-risk genotypes.
1956 controls total.
272 CIMP+ cases total.
348 KRAS2 cases total.
516 TP53 cases total.
185 MSI+ cases total.
74 CIMP+ and KRAS2 cases total.
108 CIMP and MSI+ cases total.