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. 1987 May;84(10):3400–3404. doi: 10.1073/pnas.84.10.3400

Working principles in the immune system implied by the "peptidic self" model.

P Kourilsky, G Chaouat, C Rabourdin-Combe, J M Claverie
PMCID: PMC304878  PMID: 3494999

Abstract

The hypothesis that self as well as foreign proteins are processed into peptides and presented by major histocompatibility complex antigens leads to a set of working principles that could govern cellular interactions in immune responses. In particular, "idiopeptides," derived from immunoglobulins and T-cell receptors and recognized by appropriate T cells, are expected to play an important regulatory role. We show here that these speculations fit into a consistent view of the immune system.

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Selected References

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