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. 1987 May;84(10):3430–3433. doi: 10.1073/pnas.84.10.3430

Linkage of the Wiskott-Aldrich syndrome with polymorphic DNA sequences from the human X chromosome.

M Peacocke, K A Siminovitch
PMCID: PMC304884  PMID: 3472214

Abstract

The Wiskott-Aldrich syndrome (WAS) is one of several human immunodeficiency diseases inherited as an X-linked trait. The location of WAS on the X chromosome is unknown. We have studied 10 kindreds segregating for WAS for linkage with cloned, polymorphic DNA markers and have demonstrated significant linkage between WAS and two loci, DXS14 and DXS7, that map to the proximal short arm of the X chromosome. Maximal logarithm of odds (lod scores) for WAS-DXS14 and WAS-DXS7 were 4.29 (at theta = 0.03) and 4.12 (at theta = 0.00), respectively. Linkage data between WAS and six marker loci indicate the order of the loci to be (DXYS1-DXS1)-WAS-DXS14-DXS7-(DXS84-OTC). These results suggest that the WAS locus lies within the pericentric region of the X chromosome and provide an initial step toward identifying the WAS gene and improving the genetic counseling of WAS families.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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