Figure 4.
TH does not influence the abundance of progenitors in the CMZ, but stimulates the maturation of Müller glia in far peripheral regions of the retina. Treated eyes received injections of 2 μg of TH at P0, P1, P2 and P4, whereas control eyes received injections of vehicle. Vertical sections of the far peripheral retina were labeled with antibodies to Sox9 and glutamine synthetase (GS; a and b), PCNA (c and d), and Sox9 and transitin (e and f). Retinas were obtained from eyes treated with vehicle (a, c and e) or 4 consecutive daily injections of TH (b, d and f). The calibration bar (50 μm) in a applies to a alone, and the bar in e applies to c–e. Abbreviations: ONL – outer nuclear layer, INL – inner nuclear layer, IPL – inner plexiform layer, GCL – ganglion cell layer.